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Anti-GZMB / Granzyme B Antibody (clone GrB-7) LS-C134855


Wt. Vol. Conc. Price
- 1000 µl - $325
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular GZMB / Granzyme B Antibodies

Anti-GZMB / Granzyme B Antibody (clone GB11) LS-C44295
Mouse Monoclonal [clone GB11] (IgG1) to Human GZMB / Granzyme B
Human, Monkey, Rhesus monkey
IHC - Frozen, Immunoprecipitation, Flow Cytometry, ELISA
Anti-GZMB / Granzyme B Antibody (N-Terminus) IHC-plus™ LS-B2783
Rabbit Polyclonal to Human GZMB / Granzyme B
Human, Mouse, Rat
IHC - Paraffin
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone GrB-7] (IgG2a) to Human GZMB / Granzyme B
IHC - Paraffin, IHC - Frozen, Western blot


Human GZMB / Granzyme B
Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [GrB-7]
Tissue culture supernatant


  • IHC - Paraffin
  • IHC - Frozen
  • Western blot

Specificity and Use

The monoclonal antibody reacts with the 33 kD human serine protease granzyme B. It does not react with human granzyme A. It is used as a marker for NK-cells and activated cytotoxic T-cells (CTL). This protease is localized in cytoplasmic granules and gives a granular staining pattern. Granzyme B is involved in target cell apoptosis during lymphocyte mediated cyto-toxicity. Exocytosis of granzyme containing granules in the cytoplasm of the target cell will lead to induction of DNA fragmentation and apoptosis of the target cell.
The monoclonal antibody stains granzyme B expressing lymphocytes in sections of sublimate formaldehyde as well as formalin fixed paraffin embedded tissues. It does not react with other cell types. The antibody can not be used on frozen sections. The antibody is useful for staining granzyme B protein on Western blot. Before use in immunocytochemistry the slides have to be pretreated with 0.1 M sodium citrate, for 10 min. at 100°C (in microwave oven). A working dilution of 1:20 is advised but optimal dilution should be tested by serial dilution.


Tissue culture supernatant, 1% BSA, 0.1% sodium azide
Store at -20°C.
For research use only.

About GZMB / Granzyme B

P10144 NM_004131 NP_004122.2

GZMB Antibody, CCPI Antibody, CGL-1 Antibody, Cathepsin G-like 1 Antibody, CSP-B Antibody, CTLA-1 Antibody, CTLA1 Antibody, CGL1 Antibody, CSPB Antibody, Fragmentin 2 Antibody, GRB Antibody, HLP Antibody, Human lymphocyte protein Antibody, Fragmentin-2 Antibody, SECT Antibody, Lymphocyte protease Antibody, T-cell serine protease 1-3E Antibody, C11 Antibody, CTSGL1 Antibody, Cytotoxic serine protease B Antibody, Granzyme B Antibody, Granzyme-2 Antibody

This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

Requested From: United States
Date Requested: 10/27/2016

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