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GZMA / Granzyme A
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
| Gene Name: | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | GZMA, CTLA3, CTL tryptase, Granzyme-1, H factor, HF, HFSP, Granzyme A, Fragmentin-1, Hanukah factor, Hanukkah factor |
| Target Sequences: | NM_006144 NP_006135.1 P12544 |
Publications (5)
1
Lesional CD4+ IFN-?+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis. Maehara T, Mattoo H, Ohta M, Mahajan VS, Moriyama M, Yamauchi M, Drijvers J, Nakamura S, Stone JH, Pillai SS. Annals of the rheumatic diseases. 2017 February;76:377-385. (Human)
[Full Text Article]
[PubMed:27358392]
[PMC:PMC5435236]
Related Antibodies: LS-C312742.
2
Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis. Takashi Maehara, Naoki Kaneko, Cory A Perugino, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay S Mahajan, Hang Liu, Samuel Jh Murphy, Musie Ghebremichael, David Fox, Aimee S Payne, Robert Lafyatis, John H Stone, Dinesh Khanna, Shiv Pillai. The Journal of clinical investigation. 2020 May;130:2451-2464. [Full Text Article]
[PubMed:31990684]
[PMC:PMC7190971]
Related Antibodies: LS-C312742.
3
CD4+ and CD8+ cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG4-related disease. Cory A Perugino, Naoki Kaneko, Takashi Maehara, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay S Mahajan, Hang Liu, Emanuel Della-Torre, Samuel J H Murphy, Musie Ghebremichael, Zachary S Wallace, Marcy B Bolster, Liam M Harvey, Geetha Mylvaganam, Yesim Tuncay, Lloyd Liang, Sydney B Montesi, Xiuwei Zhang, Akira Tinju, Keita Mochizuki, Ryusuke Munemura, Mizuki Sakamoto, Masafumi Moriyama, Seiji Nakamura, Nir Yosef, John H Stone, Shiv Pillai. The Journal of allergy and clinical immunology. 2021 January;147:368-382. [Full Text Article]
[PubMed:32485263]
[PMC:PMC7704943]
Related Antibodies: LS-C312742.
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GZMA / Granzyme A
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(1)
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(1)
Publications
No
(72)
Yes
(1)
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(4)
Cell Lysates
(5)
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(15)
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(15)
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(6)
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Human
(7)
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293E Cells
(1)
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(1)
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(1)
HEK 293 Cells
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(5)
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Low endotoxin level
(1)
GZMA / Granzyme A Rabbit anti-Human Polyclonal (aa175-190) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
GZMA / Granzyme A Mouse anti-Human Monoclonal (GA6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
0.1 mg/$385
GZMA / Granzyme A Rabbit anti-Mouse Polyclonal (aa29-260) Antibody
Mouse, Human
ICC, IP, WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
GZMA / Granzyme A Rabbit anti-Mouse Polyclonal (aa29-260) (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$311; 200 µl/$353; 500 µl/$496; 1 ml/$567; 2 ml/$769; 5 ml/$1,248
GZMA / Granzyme A Rabbit anti-Mouse Polyclonal (aa29-260) (APC) Antibody
Mouse, Human
WB
APC Conjugated
100 µl/$392; 200 µl/$470; 500 µl/$798; 1 ml/$951; 2 ml/$1,211; 5 ml/$2,269
Sandwich
96-Well Strip Plate
Monkey
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Strip Plate
Mouse
3.12 - 200 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
GZMA / Granzyme A Rabbit anti-Human Polyclonal (aa110-159) Antibody
Human
WB
Unconjugated
100 µl/$424
Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
GZMA / Granzyme A Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
GZMA / Granzyme A Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
GZMA / Granzyme A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
GZMA / Granzyme A Mouse anti-Human Monoclonal (4C6) Antibody
Human
ELISA
Unconjugated
100 µg/$423
GZMA / Granzyme A Mouse anti-Human Monoclonal (CB9) Antibody
Human
Flo, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$350
E. coli
His
27.2 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
Sandwich
96-Well Microplate
Mouse
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
GZMA / Granzyme A Rabbit anti-Human Polyclonal (aa61-110) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
293E Cells
10His, C-terminus
Less than 1 EU/µg (determined by LAL method).
This 252 amino acid recombinant protein has a predicted molecular mass of approximately 28 kD. The protein migrates at about 35 kD in DTT-reducing conditions and about 55 kD in non-reducing conditions by SDS-PAGE.The predicted N-terminal amino acid is Cys
10 µg/$352; 25 µg/$493
GZMA / Granzyme A Rabbit anti-Human Polyclonal (30-110 aa, Internal) Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
GZMA / Granzyme A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
GZMA / Granzyme A Mouse anti-Human Monoclonal (aa22-262) Antibody
Human
ELISA, IHC, IP
Unconjugated
100 µg/$941
GZMA / Granzyme A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
GZMA / Granzyme A Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µg/$597
GZMA / Granzyme A Mouse anti-Human Monoclonal (Concentrated) (GA6) Antibody
Human
IHC, IHC-P, WB
Unconjugated, Concentrated
0.1 mg/$531
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product results
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