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GTPCH1 / GCH1
GTP cyclohydrolase 1
GTPCH1 / GCH1 is a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
| Gene Name: | GTP cyclohydrolase 1 |
| Synonyms: | GCH1, DYT14, DYT5a, Dystonia 14, GTP cyclohydrolase 1, GTP cyclohydrolase I, GTPCH1, HPABH4B, GTP-CH-1, DYT5, GCH, GTP-CH-I |
| Target Sequences: | NM_000161 NP_000152.1 P30793 |
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Wheat Germ Extract
GST
53.24 kDa
10 µg/$479; 25 µg/$670
GTPCH1 / GCH1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
GTPCH1 / GCH1 Rabbit anti-Human Polyclonal (aa50-100) Antibody
Mouse, Human
IP, WB
Unconjugated
100 µl/$467
GTPCH1 / GCH1 Goat anti-Human Polyclonal (aa150-161) Antibody
Xenopus, Chicken, Bovine, Bat, Pig, Horse, Dog, Human, Monkey
IHC-P, Peptide-ELISA, WB
Unconjugated
100 µg/$503
GTPCH1 / GCH1 Rabbit anti-Human Polyclonal (aa39-88) Antibody
Human
WB
Unconjugated
100 µl/$424
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI3A3) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI3A3) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI1E3) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1E3) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (4A12) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$423
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI1A3) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1A3) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI2E2) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI2E2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI2D12) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI2D12) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI7B8) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI7B8) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI5A1) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI5A1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GTPCH1 / GCH1 Rabbit anti-Human Polyclonal (aa39-67) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI3C9) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI3C9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI8C6) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI8C6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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