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Anti-GTPCH1 / GCH1 Antibody (clone 4A12) LS-C133216


Wt. Vol. Conc. Price
100 µg - 0.5 mg/ml Unavailable

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100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 4A12] (IgG2a,k) to Human GTPCH1 / GCH1
Western blot, Immunoprecipitation, ELISA


Human GTPCH1 / GCH1
Human (tested or 100% immunogen sequence identity)
IgG2a,k Monoclonal [4A12]
Purified from ascites by Protein A


  • Western blot
  • Immunoprecipitation

  • IHC - Paraffin

Specificity and Use

GTPCH1 / GCH1 antibody was raised against gCH1 (NP_000152, 84 a.a. ~ 173 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Human GTP Cyclohydrolase I
Sandwich ELISA: Recombinant protein. Western Blot: Cell lysate, Transfected lysate, Recombinant protein.


PBS, pH 7.2
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
For research use only.

About GTPCH1 / GCH1

P30793 NM_000161 NP_000152.1

GCH1 Antibody, DYT14 Antibody, DYT5a Antibody, Dystonia 14 Antibody, GTP cyclohydrolase 1 Antibody, GTP cyclohydrolase I Antibody, GTPCH1 Antibody, HPABH4B Antibody, GTP-CH-1 Antibody, DYT5 Antibody, GCH Antibody, GTP-CH-I Antibody

GTPCH1 / GCH1 is a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia.

Western blot

Western blot
Western blot of GCH1 expression in transfected 293T cell line by GCH1 monoclonal antibody (M01), clone 4A12.

Western blot

Western blot
GCH1 monoclonal antibody (M01), clone 4A12 Western blot of GCH1 expression in IMR-32.


Immunoprecipitation of GCH1 transfected lysate using anti-GCH1 monoclonal antibody and Protein A Magnetic Bead.

Enzyme-Linked Immunosorbent Assay

Enzyme-Linked Immunosorbent Assay
Detection limit for recombinant GST tagged GCH1 is approximately 0.3 ng/ml as a capture antibody.

Requested From: 
Date Requested: 4/23/2017

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