Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey, Bat, Horse, Rabbit (tested or 100% immunogen sequence identity)
Mouse, Rat, Dog, Hamster, Chicken (at least 90% immunogen sequence identity)
IHC - Paraffin (21 µg/ml)
Specificity and Use
GRM8 / MGLUR8 antibody was raised against synthetic 18 amino acid peptide from N-terminal extracellular domain of human GRM8 / MGLUR8. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Baboon, Monkey, Galago, Marmoset, Shrew, Bat, Rabbit, Horse, Armadillo (100%); Mouse, Rat, Hamster, Dog, Opossum, Chicken, Platypus (94%); Zebra finch, Xenopus, Zebrafish (89%).
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.