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20700 44th Avenue W
Lynnwood, WA 98036
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GRM6 / MGLUR6
glutamate receptor, metabotropic 6
Metabotropic Glutamate Receptor GRM6 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7, and GRM8. Group II and Group III receptors are linked to the inhibition of the cyclic AMP signaling cascade, but differ in their agonist selectivities.
| Gene Name: | glutamate receptor, metabotropic 6 |
| Family/Subfamily: | GPCR , Metabotropic glutamate |
| Synonyms: | GRM6, CSNB1B, GPRC1F, MGlu6, MGLUR6 |
| Target Sequences: | NM_000843 AAB82068.1 O15303 |
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