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Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Gene Name: | G protein-coupled receptor kinase 6 |
Family/Subfamily: | Protein Kinase , GPRK |
Synonyms: | GRK6, GPRK6 |
Target Sequences: | NM_002082 NP_002073.2 P43250 |
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