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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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GRIN2B / NMDAR2B / NR2B Antibody (aa20‑271, clone S59‑36) IHC‑plus™ LS‑B7462
Note: This antibody replaces LS-C109033
NR2B antibody LS-B7462 is an unconjugated mouse monoclonal antibody to NR2B (GRIN2B / NMDAR2B) from human, mouse and rat. Validated for ICC, IHC, IP and WB. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-B7462-50
50 µg (1 mg/ml)
Unavailable

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Product Description

NR2B antibody LS-B7462 is an unconjugated mouse monoclonal antibody to NR2B (GRIN2B / NMDAR2B) from human, mouse and rat. Validated for ICC, IHC, IP and WB. Tested on 20 paraffin-embedded human tissues.
About GRIN2B / NMDAR2B / NR2B
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. Q13224 NM_000834 NP_000825.2

GRIN2B Antibody, GluN2B Antibody, GluR epsilon 2 Antibody, NMDA receptor 2B Antibody, NMDAR2B Antibody, NR2B Antibody, NR3 Antibody, MRD6 Antibody, HNR3 Antibody


Specifications

Target
Rat GRIN2B / NMDAR2B / NR2B
Host
Mouse
Reactivity
Rat, Human, Mouse (tested or 100% immunogen sequence identity)
Clonality
IgG2b Monoclonal [S59-36]
Conjugations
Unconjugated. Also available conjugated with Atto 390, Atto 488, Atto 565, Atto 594, Atto 633, Atto 655, Atto 680, AP, Atto 700, APC, Biotin, FITC, PE, Atto 594, PerCP, RPE, SA.
Purification
Protein G purified from tissue culture supernatant
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (5 µg/ml)
  • ICC (0.1 - 1 µg/ml)
  • Western blot (1 - 10 µg/ml)
  • Immunoprecipitation (1 - 10 µg/ml)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Fusion protein amino acids 20-271 (extracellular N-terminus) of rat NR2B, accession number Q00960.
Epitope
aa20-271
Specificity
Detects ~166 kD protein. No cross reactivity against NR2A.
Presentation
PBS, pH 7.4, 50% glycerol, 0.09% sodium azide
Storage
Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

Anti-GRIN2B / NMDAR2B antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7462 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-GRIN2B / NMDAR2B antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7462 concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Anti-GRIN2B / NMDAR2B antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7462 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-GRIN2B / NMDAR2B antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7462 concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Anti-GRIN2B / NMDAR2B antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7462 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-GRIN2B / NMDAR2B antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7462 concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Anti-GRIN2B / NMDAR2B antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7462 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-GRIN2B / NMDAR2B antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7462 concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.


Requested From: 
Date Requested: 6/22/2018

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