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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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GRG4 / TLE4 Antibody (aa262‑290) LS‑C161912
TLE4 antibody LS-C161912 is an unconjugated mouse monoclonal antibody to human TLE4 (GRG4). Validated for WB.
Catalog
Size
Price
LS-C161912-100
100 µl
Unavailable

Popular GRG4 / TLE4 Products

Anti-TLE4 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6530 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Mouse, Rat, Bat, Dog, Guinea pig, Horse, Pig, Rabbit, Chicken
Applications: IHC, IHC - Paraffin, Western blot
Human, Small Intestine: Formalin-Fixed Paraffin-Embedded (FFPE)
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot, ELISA
Immunohistochemical analysis of TLE4 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Species: Human, Mouse, Rat, Chicken
Applications: IHC, IHC - Paraffin, Western blot
Western blot of TLE4 antibody
Species: Human, Mouse, Rat
Applications: IHC, Western blot, ELISA

Product Description

TLE4 antibody LS-C161912 is an unconjugated mouse monoclonal antibody to human TLE4 (GRG4). Validated for WB.
About GRG4 / TLE4
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression. Q04727 NM_007005 NP_008936.2

TLE4 Antibody, BCE1 Antibody, BCE-1 Antibody, E(spI) Antibody, Enhancer of split groucho 4 Antibody, ESG Antibody, ESG4 Antibody, GRG4 Antibody, Protein BCE-1 Antibody, KIAA1261 Antibody, R-esp2 Antibody, B lymphocyte gene 1 Antibody


Specifications

Target
Human GRG4 / TLE4
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Mouse, Rat (at least 90% immunogen sequence identity)
Clonality
IgM Monoclonal
Conjugations
Unconjugated
Purification
Ascites
Modifications
Unmodified
Applications
  • Western blot (1:100 - 1:3200)
Epitope
aa262-290
Specificity
This TLE4 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 262-290 amino acids from the Central region of human TLE4.
Presentation
Ascites, 0.09% sodium azide
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Western blot

TLE4 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The TLE4 antibody detected the TLE4 protein (arrow).
TLE4 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The TLE4 antibody detected the TLE4 protein (arrow).

Western blot

TLE4 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The TLE4 antibody detected the TLE4 protein (arrow).
TLE4 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The TLE4 antibody detected the TLE4 protein (arrow).

Western blot

TLE4 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The TLE4 antibody detected the TLE4 protein (arrow).
TLE4 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The TLE4 antibody detected the TLE4 protein (arrow).

Western blot

TLE4 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The TLE4 antibody detected the TLE4 protein (arrow).
TLE4 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The TLE4 antibody detected the TLE4 protein (arrow).


Requested From: 
Date Requested: 6/19/2018

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