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Anti-GRB2 Antibody (aa54-62) LS-C7289

Ordering

Wt. Vol. Conc. Price
100 µg - - $590
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

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Mouse Monoclonal (IgG1,k) to Human GRB2
Human, Mouse, Rat, Bovine, Xenopus
IHC - Paraffin, IHC - Frozen, Immunofluorescence, Western blot
Unconjugated

Details

Human GRB2
Mouse
Human, Mouse, Rat, Bovine, Xenopus (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal
Protein G purified

Applications

IHC - Paraffin, IHC - Frozen, Immunofluorescence (1 µg/ml), Western blot

Specificity and Use

GRB2 antibody was raised against purified recombinant human Grb2 protein.
aa54-62
Recognizes a protein with Mr24-25kD, identified as Grb2 (growth-factor receptor-bound protein 2), also known as ASH (abundant Src homology). Grb2 deletion studies indicate that the epitope for this antibody maps to amino acid residues 54-62. No cross-reactivity with other SH2/SH3 signaling intermediates. Species Reactivity: Human, bovine, mouse, rat and Xenopus.
Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry. Immunofluorescence: 1.0 ug/ml with an incubation of 2 hours at RT. Immunohistochemistry: 1-2 ug/ml with an incubation of 30 minutes at RT. (on acetone-fixed frozen and formalin-fixed/paraffin-embedded tissue sections. Staining of formalin/paraffin tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes.). Positive control: BALB 3T3 or NIH 3T3 cells, kidney or tonsil.

Packaging

PBS, pH 7.4, 0.2% BSA, 15 mM sodium azide.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
For research use only.

About GRB2

P62993 NM_002086 NP_002077.1

GRB2 Antibody, Abundant SRC homology Antibody, Adapter protein GRB2 Antibody, ASH Antibody, EGFRBP-GRB2 Antibody, MST084 Antibody, MSTP084 Antibody, Protein Ash Antibody, SH2/SH3 adapter GRB2 Antibody, Grb3-3 Antibody, HT027 Antibody, NCKAP2 Antibody

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

Requested From: United States
Date Requested: 9/24/2016

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