Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Granulocyte antibody was raised against peritoneal cells
The antigen is localized on the cell surface. The epitope has not been further characterized. Antigen distribution: Isolated cells Only a low percentage of cells from peripheral blood stains positive. Positive on peritoneal cells 18h after thioglycollate injection (95% granulocytes). Negative on peritoneal cells 4 days after thioglycollate injection. Negative on isolated lymphocytes, monocytes, erythrocytes and platelets. Specificity: Rat: pan-granulocytes,. Other species: human: negative, other species not tested. Tissue staining: RK-4 reaction pattern: Tissues tested Results Bone marrow positive on granulocytes positive on granulocyte precursors positive on segmented cells positive on band cells positive on metamyelocytes positive on myelocytes Lung negative on alveolar macrophages; interstitial tissues are occasionally positive. Kidney negative; on perivascular granulocytes occasionally positive. Skin negative; on perivascular granulocytes occasionally positive. Liver negative; on perivascular granulocytes occasionally positive. Blood vessel wall negative
Lyophilized from PBS pH 7.2, 10mg/ml BSA, 0.01% thimerosal