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Anti-GPR49 / LGR5 Antibody (N-Terminus) IHC-plus™ LS-A1232

Ordering

Wt. Vol. Conc. Price
50 µg 50 µl 1 mg/ml $395
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Most Popular GPR49 / LGR5 Antibodies

Anti-GPR49 / LGR5 Antibody (Cytoplasmic Domain) IHC-plus™ LS-A1236
Rabbit Polyclonal to Human GPR49 / LGR5
Human
IHC - Paraffin
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed In Stock In Stock Publications Publications (3)
Rabbit Polyclonal to Human GPR49 / LGR5
Human, Monkey, Bat
IHC - Paraffin
Unconjugated

Details

Human GPR49 / LGR5
Rabbit
Human, Monkey, Bat (tested or 100% immunogen sequence identity)
Mouse, Rat, Bovine (at least 90% immunogen sequence identity)
Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

IHC - Paraffin (1:400)

Specificity and Use

GPR49 / LGR5 antibody was raised against synthetic 20 amino acid peptide from N-terminal extracellular domain of human GPR49 / LGR5. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Bat (100%); Elephant, Panda (95%); Mouse, Rat, Bovine (90%); Opossum (85%); Rabbit, Chicken (80%).
LS-E28193 - Liquid - 50 µg - $145.00
N-Terminus
Human GPR49 / LGR5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Packaging

PBS, less than 0.1% sodium azide.
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze thaw cycles.
For research use only.

Publications (3)

1
EP receptor expression in human intestinal epithelium and localization relative to the stem cell zone of the crypts. Olsen Hult LT, Kleiveland CR, Fosnes K, Jacobsen M, Lea T. PloS one. 2011 6:e26816. (ICC, IHC-P; Human) [Full Text Article] [PubMed:22046368] [PMC:PMC3201980]
2
Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis. Takeda K, Kinoshita I, Shimizu Y, Matsuno Y, Shichinohe T, Dosaka-Akita H. Anticancer research. 2011 Jan;31:263-70. [Full Text Article] [PubMed:21273608]
3
LGR5 is a marker of poor prognosis in glioblastoma and is required for survival of brain cancer stem-like cells. Nakata S, Campos B, Bageritz J, Bermejo JL, Becker N, Engel F, Acker T, Momma S, Herold-Mende C, Lichter P, Radlwimmer B, Goidts V. Brain pathology (Zurich, Switzerland). 2013 Jan;23:60-72. [Full Text Article] [PubMed:22805276]

About GPR49 / LGR5

O75473 NM_003667 NP_003658.1

LGR5 Antibody, FEX Antibody, G-protein coupled receptor 49 Antibody, G protein-coupled receptor 49 Antibody, GPR67 Antibody, GRP49 Antibody, GPR49 Antibody, HG38 Antibody, G-protein coupled receptor 67 Antibody

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.

Immunohistochemistry

Immunohistochemistry
Human, Pancreas, Islets: Formalin-Fixed Paraffin-Embedded (FFPE)
 

Requested From: United States
Date Requested: 12/6/2016

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