Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Western blot (1:500 - 1:1000)
Specificity and Use
GPR44 / CRTH2 antibody was raised against human CRTH2 protein.
Recognizes human CRTH2 (Chemoattractant Receptor Homologous molecule), a member of the G protein-coupled leukocyte chemoattractant receptor family. CRTH2 is expressed by Th2, but not Th1 cells, in response to activators such as allergens.
Western Blot: 1A band of approximately 55-70 kD is detected.
PBS, pH 7.4, 0.02% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.