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| Catalog Number | Size | Price |
|---|---|---|
| LS-A45-50 | 50 µg (1 mg/ml) | $440 |
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PathPlus™ Polyclonal Rabbit anti‑Human GPR183 / EBI2 Antibody (Extracellular Domain, IHC) LS‑A45
PathPlus™ Polyclonal Rabbit anti‑Human GPR183 / EBI2 Antibody (Extracellular Domain, IHC) LS‑A45
Antibody:
GPR183 / EBI2 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Overview
Antibody:
GPR183 / EBI2 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Specifications
Description
G protein-coupled receptor 183 (GPR183) is a receptor for oxysterol 7-alpha, 25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. GPR183 promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). GPR183 signals constitutively through G(i)-alpha, but not through G(s)-alpha or G(q)-alpha, and it also signals constitutively via MAPK1/3 (ERK1/2).
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human GPR183 / EBI2
Synonyms
GPR183 | EBI 2 | EBI2 | EBV-induced gene 2 | G protein-coupled receptor 183 | G-protein coupled receptor 183
Host
Rabbit
Reactivity
Human, Monkey
(tested or 100% immunogen sequence identity)
Predicted
Bovine (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 18 amino acid peptide from 2nd extracellular domain of human GPR183 / EBI2. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Bovine (94%); Hamster, Panda, Bat, Dog, Pig (89%); Marmoset, Horse (83%).
Epitope
Extracellular Domain
Specificity
Human GPR183 / EBI2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except NBEA (39%).
Applications
- IHC
- IHC - Paraffin (3 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About GPR183 / EBI2
Validation
Brain, Cortex neurons
Brain, Cortex neurons
Anti-GPR183 / EBI2 antibody IHC of human peripheral blood leukocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR183 / EBI2 antibody IHC of human peripheral blood leukocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Ovary, Carcinoma
Ovary, Carcinoma
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Colon, adenocarcinoma
Colon, adenocarcinoma
See More About...
LSBio Ratings
PathPlus™ GPR183 / EBI2 Antibody (Extracellular Domain) for IHC LS-A45 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin
Reactivity:
Pig
Range:
78-5000 pg/ml
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/16/2024
Date Requested: 4/16/2024
