Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 3E1] (IgG1,k) to Human GPN1 / XAB1
IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Human GPN1 / XAB1
Human (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [3E1]
Protein A purified
IHC - Paraffin (5 µg/ml)
Immunofluorescence (10 µg/ml)
Specificity and Use
GPN1 / XAB1 antibody was raised against xAB1 (AAH07451, 9 a.a. ~ 119 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Western Blot (Cell lysate) - positive control HL-60. Western Blot (Transfected lysate) - positive control transfected 293T cell line. Immunofluorescence (10 ug/ml) - positive control HeLa cells. Sandwich ELISA (Recombinant protein).
PBS, pH 7.2
Store at -20°C. Aliquot to avoid freeze/thaw cycles.
GPN1 Antibody, ATP(GTP)-binding protein Antibody, ATPBD1A Antibody, GPN-loop GTPase 1 Antibody, MBD2-interacting protein Antibody, RPAP4 Antibody, XPA binding protein 1, GTPase Antibody, MBDIN Antibody, NTPBP Antibody, XAB1 Antibody, XPA binding protein 1 Antibody, XPA-binding protein 1 Antibody
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119).