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GPIHBP1

glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

GPIHBP1 is a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants.

Gene Name: glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Synonyms: GPIHBP1, GPI-HBP1, LOC338328
Target Sequences: NM_178172 NP_835466.2 Q8IV16

Publications (4)

1
Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase. Beigneux AP, Gin P, Davies BS, Weinstein MM, Bensadoun A, Ryan RO, Fong LG, Young SG. Journal of lipid research. 2008 49:1312-21. (IHC) [PubMed:18340083] [PMC:PMC3055742]
2
The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons. Gin P, Yin L, Davies BS, Weinstein MM, Ryan RO, Bensadoun A, Fong LG, Young SG, Beigneux AP. The Journal of biological chemistry. 2008 283:29554-62. [PubMed:18713736] [PMC:PMC2662032]
3
The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. Davies BS, Waki H, Beigneux AP, Farber E, Weinstein MM, Wilpitz DC, Tai LJ, Evans RM, Fong LG, Tontonoz P, Young SG. Molecular endocrinology (Baltimore, Md.). 2008 22:2496-504. [PubMed:18787041] [PMC:PMC2582544]
4
Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase. Beigneux AP, Gin P, Davies BS, Weinstein MM, Bensadoun A, Fong LG, Young SG. The Journal of biological chemistry. 2009 284:30240-7. [PubMed:19726683] [PMC:PMC2781579]
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☰ Filters
Antibodies (18)
Proteins (5)
ELISA Kits (1)
Over-Expression Lysate (2)
Primary (18)
Recombinant (3)
Sandwich (1)
GPIHBP1 (24)
Human (13)
Mouse (6)
Chimpanzee (3)
Gibbon (3)
IHC (2)
IHC-P (2)
WB (13)
ELISA (6)
rabbit (18)
IgG (7)
polyclonal pc (18)
96-Well Strip Plate (1)
Biotin Conjugated (3)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (8)
Internal (5)
C-Terminus (4)
aa170-250 (1)
No (24)
Tissue Homogenates (1)
Fc, C-terminus (1)
GST (1)
GST, N-terminus + His, C-terminus (1)
Myc-DDK (Flag) (2)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Human (1)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (1)
GPIHBP1 Antibody - Immunohistochemistry of paraffin-embedded human skin tissue at dilution of 1:100
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GPIHBP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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GPIHBP1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
GPIHBP1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
GPIHBP1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
Select
GPIHBP1 Rabbit anti-Mouse Polyclonal (Internal) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
100 µl/$603
GPIHBP1 Antibody - Detection of Gpihbp1 in transfected lysate (Lane 1). An empty vector lysate was used as a negative control (Lane 2).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPIHBP1 Rabbit anti-Mouse Polyclonal (aa170-250) Antibody
Mouse
WB
Unconjugated
0.1 ml/$386
GPIHBP1 Antibody - Detection of Gpihbp1 in transfected lysate (Lane 1). An empty vector lysate was used as a negative control (Lane 2).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPIHBP1 Rabbit anti-Mouse Polyclonal (Internal) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
0.1 ml/$416
GPIHBP1 Antibody - Detection of Gpihbp1 in transfected lysate (Lane 1). An empty vector lysate was used as a negative control (Lane 2).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPIHBP1 Rabbit anti-Mouse Polyclonal (Internal) (DY488) Antibody
Mouse
WB
DY488 Conjugated
0.1 ml/$416
GPIHBP1 Antibody - Detection of Gpihbp1 in transfected lysate (Lane 1). An empty vector lysate was used as a negative control (Lane 2).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPIHBP1 Rabbit anti-Mouse Polyclonal (Internal) (DY550) Antibody
Mouse
WB
DY550 Conjugated
0.1 ml/$416
GPIHBP1 Antibody - Detection of Gpihbp1 in transfected lysate (Lane 1). An empty vector lysate was used as a negative control (Lane 2).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
GPIHBP1 Rabbit anti-Mouse Polyclonal (Internal) (DY650) Antibody
Mouse
WB
DY650 Conjugated
0.1 ml/$416
Select
GPIHBP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
Select
GPIHBP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
GPIHBP1 Antibody - GPIHBP1 antibody Western Blot of HepG2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPIHBP1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
GPIHBP1 Antibody - GPIHBP1 antibody Western Blot of HepG2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPIHBP1 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human, Chimpanzee, Gibbon
WB
HRP Conjugated
100 µl/$469
GPIHBP1 Antibody - GPIHBP1 antibody Western Blot of HepG2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
GPIHBP1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human, Chimpanzee, Gibbon
WB
Biotin Conjugated
100 µl/$469
GPIHBP1 Antibody - GPIHBP1 antibody Western Blot of HepG2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPIHBP1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human, Chimpanzee, Gibbon
WB
FITC Conjugated
100 µl/$469
GPIHBP1 Antibody - Western blot analysis of extracts of various cell lines, using GPIHBP1 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
Select
GPIHBP1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
GPIHBP1 Antibody - Western blot analysis of extracts of various cell lines using GPIHBP1 Polyclonal Antibody at dilution of 1:3000.
Select
GPIHBP1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
GPIHBP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
19.6 kDa
20 µg/$150
GPIHBP1 Protein - 12.5% SDS-PAGE of human GPIHBP1 stained with Coomassie Blue
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Wheat Germ Extract
GST
46.2 kDa
10 µg/$479; 25 µg/$670
GPIHBP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
19.6 kDa
100 µg/$494
GPIHBP1 Protein
Select
E. coli
GST, N-terminus + His, C-terminus
45.6 kDa
50 µg/$419
GPIHBP1 Protein - Recombinant Human GPIHBP1 (C-Fc)
Select
Human
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.7 kDa
10 µg/$329; 50 µg/$580
GPIHBP1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$902
Viewing 1-24 of 24 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).