Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey (tested or 100% immunogen sequence identity)
Pig (at least 90% immunogen sequence identity)
IHC - Paraffin (3.75 µg/ml)
Western blot (0.1 - 0.3 µg/ml)
Specificity and Use
GPI antibody was raised against synthetic peptide C-RERMFNGEKINYT from an internal region (near N-terminus) of human GPI (NP_000166.2). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Monkey, Marmoset (100%); Elephant, Pig (92%); Panda, Bovine, Dog, Horse, Chicken, Platypus (85%).
GPI is a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate.