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| Catalog Number | Size | Price |
|---|---|---|
| LS-A209-50 | 50 µg (1 mg/ml) | $440 |
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PathPlus™ Polyclonal Rabbit anti‑Human GnRH receptor / GNRHR Antibody (Cytoplasmic Domain, IHC) LS‑A209
PathPlus™ Polyclonal Rabbit anti‑Human GnRH receptor / GNRHR Antibody (Cytoplasmic Domain, IHC) LS‑A209
Antibody:
GnRH receptor / GNRHR Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Overview
Antibody:
GnRH receptor / GNRHR Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
Gonadotropin-releasing hormone receptor (GNRHR) is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. GNRHR is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of GNRHR ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH).
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human GnRH receptor / GNRHR
Synonyms
GNRHR | GnRH receptor | GnRH-R | GRHR | HH7 | LHRHR | LRHR | Luliberin receptor | Type I GnRH receptor | GNRHR1 | Lh-rh receptor
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Predicted
Monkey, Bovine, Dog, Horse, Pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human GNRHR. Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Gorilla, Monkey, Dog, Elephant, Panda (95%); Marmoset, Bovine, Horse, Pig (90%); Mouse, Rat, Sheep, Bat, Rabbit, Opossum (85%); Hamster, Guinea pig (80%).
Epitope
Cytoplasmic Domain
Specificity
Human GNRHR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (1:3000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About GnRH receptor / GNRHR
Validation
Adrenal
Adrenal
Brain, pituitary
Brain, pituitary
Human Pituitary: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Pituitary: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ GnRH receptor / GNRHR Antibody (Cytoplasmic Domain) for IHC LS-A209 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Frozen, Western blot, Flow Cytometry, ELISA
Species:
Human
Applications:
IHC, IHC - Frozen, Western blot, Flow Cytometry, ELISA, Dot Blot
Species:
Human, Monkey, Dog, Guinea pig, Rabbit
Applications:
Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human
Applications:
IHC, IHC - Frozen, Western blot, Flow Cytometry, ELISA
Species:
Human, Mouse
Applications:
Immunofluorescence, Western blot, ELISA
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/19/2024
Date Requested: 4/19/2024
