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GLB1 / Beta-Galactosidase

galactosidase, beta 1

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.Isoform 2 has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.

Gene Name: galactosidase, beta 1
Synonyms: GLB1, Acid beta-galactosidase, Beta-galactosidase, Elastin receptor 1, Elastin receptor 1 (67kD), Elastin receptor 1, 67kDa, Galactosidase, beta 1, ELNR1, Lactase, MPS4B
Target Sequences: NM_000404 NP_000395.2 P16278

Publications (5)

1
SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination. Lu W, Liu S, Li B, Xie Y, Adhiambo C, Yang Q, Ballard BR, Nakayama KI, Matusik RJ, Chen Z. Oncotarget. 2015 6:771-88. (WB; Human) [PubMed:25596733] [PMC:PMC4359254]
2
DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression. Borghesan M, Fusilli C, Rappa F, Panebianco C, Rizzo G, Oben JA, Mazzoccoli G, Faulkes C, Pata I, Agodi A, Rezaee F, Minogue S, Warren A, Peterson A, Sedivy JM, Douet J, Buschbeck M, Cappello F, Mazza T, Pazienza V, Vinciguerra M. Cancer research. 2016 76:594-606. (WB; Human) [Full Text Article] [PubMed:26772755] [PMC:PMC4785885] Related Antibodies: LS-B10217.
3
Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer. Kovacovicova K, Skolnaja M, Heinmaa M, Mistrik M, Pata P, Pata I, Bartek J, Vinciguerra M. Frontiers in oncology. 2018 October;8:459. [Full Text Article] [PubMed:30425964] [PMC:PMC6218402] Related Antibodies: LS-B10217.
4
Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol. Zonis S, Breunig JJ, Mamelak A, Wawrowsky K, Bresee C, Ginzburg N, Chesnokova V. Journal of neuroinflammation. 2018 September;15:260. [Full Text Article] [PubMed:30201019] [PMC:PMC6131894] Related Antibodies: LS-B10989.
5
Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage. Vera Chesnokova, Svetlana Zonis, Athanasia Apostolou, Hannah Q Estrada, Simon Knott, Kolja Wawrowsky, Kathrin Michelsen, Anat Ben-Shlomo, Robert Barrett, Vera Gorbunova, Katia Karalis, Shlomo Melmed. Cell reports. 2021 December;37:110068. [Full Text Article] [PubMed:34910915] [PMC:PMC8716125] Related Antibodies: LS-B10989.
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Antibodies (77)
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GLB1 / Beta-Galactosidase Antibody - Anti-GLB1 / Beta-Galactosidase antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (5H2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
GLB1 / Beta-Galactosidase Antibody - Anti-GLB1 / Beta-Galactosidase antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (10B2) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
GLB1 / Beta-Galactosidase Antibody - Anti-GLB1 / Beta-Galactosidase antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (2F6) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
GLB1 / Beta-Galactosidase Antibody - IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-GLB1 mouse monoclonal antibody.
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GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (OTI1E10) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
GLB1 / Beta-Galactosidase Antibody - IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-GLB1 mouse monoclonal antibody.
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GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (Carrier-free) (OTI1E10) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GLB1 / Beta-Galactosidase Antibody - Immunohistochemistry of paraffin-embedded human colon tissue.
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GLB1 / Beta-Galactosidase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
74.63kD
10 µg/$297; 50 µg/$468; 500 µg/$1,585; 1 mg/$2,157
GLB1 / Beta-Galactosidase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
GLB1 / Beta-Galactosidase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
GLB1 / Beta-Galactosidase Antibody
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GLB1 / Beta-Galactosidase Rabbit Polyclonal Antibody
ICC, IHC, IP, WB
Unconjugated
100 µl/$425
GLB1 / Beta-Galactosidase Antibody - Immunohistochemical analysis of Beta-galactosidase staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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GLB1 / Beta-Galactosidase Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
GLB1 / Beta-Galactosidase Antibody - Immunohistochemistry of paraffin-embedded human colon cancer at dilution of 1:100
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GLB1 / Beta-Galactosidase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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GLB1 / Beta-Galactosidase Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
GLB1 / Beta-Galactosidase Antibody - GLB1 monoclonal antibody (M01), clone 6E7 Western Blot analysis of GLB1 expression in HeLa.
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GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (6E7) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$423
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GLB1 / Beta-Galactosidase Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$937
GLB1 / Beta-Galactosidase Antibody
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GLB1 / Beta-Galactosidase Mouse Monoclonal (5A3) Antibody
ICC, IHC, IP, WB
Unconjugated
100 µg/$413
GLB1 / Beta-Galactosidase Antibody - Western blot of extracts from 3T3 cells, using GLB1 antibody.
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GLB1 / Beta-Galactosidase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
GLB1 / Beta-Galactosidase Antibody - Anti-GLB1 / Beta-Galactosidase antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (Carrier-free) (5H2) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
GLB1 / Beta-Galactosidase Antibody - Western blot of recombinant GLB1 / Beta-Galactosidase.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLB1 / Beta-Galactosidase Rabbit anti-Human Polyclonal (aa68-219) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$334; 200 µl/$387; 500 µl/$565; 1 ml/$682; 2 ml/$919; 5 ml/$1,549
GLB1 / Beta-Galactosidase Antibody - Anti-GLB1 / Beta-Galactosidase antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (Carrier-free) (2F6) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GLB1 / Beta-Galactosidase Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-GLB1 mouse monoclonal antibody.
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GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (OTI1C9) Antibody
Dog, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$450
GLB1 / Beta-Galactosidase Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-GLB1 mouse monoclonal antibody.
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GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (Carrier-free) (OTI1C9) Antibody
Dog, Human, Monkey
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GLB1 / Beta-Galactosidase ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
GLB1 / Beta-Galactosidase ELISA Kit
Select
Sandwich
96-Well Microplate
Human
12.5 - 800 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$610
GLB1 / Beta-Galactosidase ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.156 - 10 mU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Viewing 1-25 of 108 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).