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GLA / Alpha Galactosidase

galactosidase, alpha

GLA / Alpha Galactosidase encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.

Gene Name: galactosidase, alpha
Synonyms: GLA, Alpha-D-galactosidase A, Alpha-galactosidase A, Galactosidase, alpha, Melibiase, Alpha-gal A, GALA
Target Sequences: NM_000169 NP_000160.1 P06280

Publications (1)

1
Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates. Xuling Zhu, Ling Yin, Matt Theisen, Jenny Zhuo, Summar Siddiqui, Becca Levy, Vladimir Presnyak, Andrea Frassetto, Jaclyn Milton, Timothy Salerno, Kerry E Benenato, Joe Milano, Andy Lynn, Staci Sabnis, Kristine Burke, Gilles Besin, Christine M Lukacs, Lin T Guey, Patrick F Finn, Paolo G V Martini. American journal of human genetics. 2019 Apr;104:625-637. [Full Text Article] [PubMed:30879639] [PMC:PMC6451694] Related Antibodies: LS-B11102.

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Antibodies (92)
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GLA / Alpha Galactosidase (121)
Human (83)
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GLA / Alpha Galactosidase Antibody - Anti-GLA / Alpha Galactosidase antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
GLA / Alpha Galactosidase Antibody - Anti-GLA / Alpha Galactosidase antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P
Biotin Conjugated
50 µg/$294; 100 µg/$360
GLA / Alpha Galactosidase Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa150-429) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
GLA / Alpha Galactosidase Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa147-371) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
GLA / Alpha Galactosidase Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa81-429) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
GLA / Alpha Galactosidase Antibody - GLA Antibody IHC of formalin-fixed and paraffin-embedded human Lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa83-112) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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GLA / Alpha Galactosidase Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$371
GLA / Alpha Galactosidase Antibody - Western blot of recombinant GLA / Alpha Galactosidase.
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GLA / Alpha Galactosidase Mouse anti-Human Monoclonal (aa1-80) Antibody
Human
WB
Unconjugated
100 µl/$305; 200 µl/$345; 500 µl/$479; 1 ml/$547; 2 ml/$725; 5 ml/$1,192
GLA / Alpha Galactosidase Antibody - Western blot of recombinant GLA / Alpha Galactosidase.
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GLA / Alpha Galactosidase Mouse anti-Human Monoclonal (aa81-429) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$314; 200 µl/$359; 500 µl/$506; 1 ml/$580; 2 ml/$797; 5 ml/$1,295
GLA / Alpha Galactosidase Antibody - Western blot of recombinant GLA / Alpha Galactosidase.
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GLA / Alpha Galactosidase Mouse anti-Human Monoclonal (aa81-429) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$342; 200 µl/$399; 500 µl/$587; 1 ml/$725; 2 ml/$962; 5 ml/$1,647
GLA / Alpha Galactosidase Antibody - Western blot of recombinant GLA / Alpha Galactosidase.
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GLA / Alpha Galactosidase Rabbit anti-Mouse Polyclonal (aa29-258) Antibody
Mouse
WB
Unconjugated
100 µg/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
GLA / Alpha Galactosidase Antibody - Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa110-159) Antibody
Human
WB
Unconjugated
100 µl/$424
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
GLA / Alpha Galactosidase ELISA Kit
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Sandwich
96-Well Microplate
Human
41 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$672
GLA / Alpha Galactosidase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
GLA / Alpha Galactosidase ELISA Kit
Select
Sandwich
96-Well Microplate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
GLA / Alpha Galactosidase ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
13.7 - 10000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$968
GLA / Alpha Galactosidase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
GLA / Alpha Galactosidase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
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GLA / Alpha Galactosidase Chicken anti-Human Polyclonal (aa55-64) Antibody
Human
ELISA, WB
Unconjugated
500 µg/$580; 100 µg/$729
GLA / Alpha Galactosidase Antibody - Western blot of recombinant GLA / Alpha Galactosidase.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa81-429) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217
GLA / Alpha Galactosidase Antibody - Immunofluorescent analysis of Alpha-galactosidase A staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
GLA / Alpha Galactosidase Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa1-80) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
GLA / Alpha Galactosidase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
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HEK 293 Cells
His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
45.6 kDa
50 µg/$970
Viewing 1-25 of 121 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).