Rat GJB3 / CX31 / Connexin 31

Rabbit

Rat (tested or 100% immunogen sequence identity)

IgG Monoclonal

Unconjugated

Purified

Unmodified

Synthetic phosphopeptide corresponding to an amino acid sequence within connexin43 which includes phosphorylated Ser368 (pSer368).

pSer368

Recognizes the ~43 kD Connexin43, when phosphorylated at Ser368. Connexin43 (CX43) allows for the exchange of solutions between neighboring cells through the formation of gap-junctional channels and is expressed in the brain, kidneys and myocardium, as well as vascular endothelial cells. A decrease in the permeability of gap-junctional channels occurs due to a conformational change in the structure of CX43, and that this is mediated by the phosphorylation of CX43 at residue Ser368, by Protein Kinase C. A possible link between CX43 and epilepsy has been investigated following the detection of high levels of CX43 in both low-grade tumors and peritumoural reactive astrocytes.

• Western blot (1:1000)

Western Blot: LS-C43142 detects a band of approximately 43kD in rat hippocampus cell lysates.

10mM HEPES, pH 7.5, 0.05% Sodium Azide, 50% Glycerol, 0.01% BSA

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: O75712 NCBI: NM_024009 NP_076872.1