Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey, Mouse, Rat, Bat, Dog, Hamster, Horse, Pig
IHC, Western blot
Human, Monkey, Mouse, Rat, Bat, Dog, Hamster, Horse, Pig (tested or 100% immunogen sequence identity)
Bovine (at least 90% immunogen sequence identity)
Specificity and Use
GFRA2 antibody was raised against a synthetic peptide (PRVEKTPSLPDDLSD) as a part of human GFR alpha-2 protein (aa: 376-390) conjugated to KLH. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Panda, Dog, Bat, Horse, Pig (100%); Orangutan, Elephant, Bovine (93%); Opossum, Platypus (87%).
Western blot analysis indicates a high level of specificity to GFR alpha-2 for this antiserum. Species cross-reactivity: This antibody is known to react with rat GFR alpha-2.
Suitable for use in Western Blot and Immunohistochemistry.
Lyophilized powder. Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.
Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRa, which is a cell surface receptor for NTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently (2-7).