Bovine GFAP

Mouse

Bovine (tested or 100% immunogen sequence identity)

IgG2b Monoclonal

2E1

Unconjugated

Protein G purified

Unmodified

Bovine spinal cord homogenate

Recognizes glial fibrillary acidic protein, or GFAP, a class III intermediate filament. During development of the central nervous system, GFAP distinguishes astrocytes from other glial cells. It is involved in various cellular functions, such as cell structure and movement, cell communication and the functioning of the blood-brain barrier. It also plays a role in mitosis by adjusting the filament network present in the cell. Defects in GFAP are a cause of Alexander disease, a rare disorder of the central nervous system affecting mostly males. It is a progressive leukoencephalopathy resulting in mental and physical retardation, dementia, seizures and early death. The antibody may be used in conjunction with clones 1B4 and 4A11 for increased sensitivity when used in immunohistology.

• IHC - Paraffin
• IHC - Frozen
• Western blot
• Radioimmunoassay

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P14136 NCBI: NM_002055 NP_002046.1