Human GFAP

Rabbit

Human, Gibbon, Monkey, Mouse, Rat, Horse, Rabbit (tested or 100% immunogen sequence identity)

Dog, Pig (at least 90% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

A synthetic peptide corresponding to a sequence at the C-Terminus of human GFAP (417-432 aa DGEVIKESKQEHKDVM). Percent identity by BLAST analysis: Human, Gibbon, Galago, Marmoset, Rat, Cat, Rabbit, Horse (100%); Pig, Dog (94%); Mouse (88%); Opossum (81%).

aa417-432

Human GFAP

• IHC
• IHC - Paraffin (0.5 - 1 µg/ml)
• Western blot (0.5 - 1 µg/ml)

Glial fibrillary acidic protein is an intermediate-filament (IF) protein that is highly specific for cells of astroglial lineage, although its tissue-specific role is speculative. Expression is also seen in rat kidney glomeruli and peritubular fibroblasts, leydig cells of testis, skin keratinocytes, osteocytes of bones, chondrocytes of epiglottis, bronchus, and stellate-shaped cells of the pancreas and liver. Its expression is essential for normal white matter architecture and blood-brain barrier integrity, and its absence leads to late-onset CNS dysmyelination. The protein has also been shown to play a role in mitosis by adjusting the filament network present in the cell. During mitosis, there is an increase in the amount of phosphorylated GFAP, and a movement of this modified protein to the cleavage furrow.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

It is recommended that deionized water (200ul) be added to the vial to prepare a stock solution of 0.5mg/mL.

Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P14136 NCBI: NM_002055 NP_002046.1