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Anti-GDF9 / GDF-9 Antibody (aa420-451, clone mAb-GDF9-53) LS-C188621

Ordering

Wt. Vol. Conc. Price
100 µg - 1 mg/ml $915
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular GDF9 / GDF-9 Antibodies

Anti-GDF9 / GDF-9 Antibody (aa45-59) IHC-plus™ LS-B809
Rabbit Polyclonal to Human GDF9 / GDF-9
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-GDF9 / GDF-9 Antibody (aa420-451, clone mAb-GDF9-53) LS-C188621
Mouse Monoclonal [clone mAb-GDF9-53] (IgG) to Human GDF9 / GDF-9
Human, Monkey, Bat, Dog
IHC - Paraffin, IHC - Frozen, Western blot, Functional Assay
Unconjugated
Western blot Image
Anti-GDF9 / GDF-9 Antibody (Biotin) LS-C319013
Rabbit Polyclonal (IgG) to Human GDF9 / GDF-9
Human
Western blot, ELISA
Biotin Conjugated

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone mAb-GDF9-53] (IgG) to Human GDF9 / GDF-9
Human, Monkey, Bat, Dog
IHC - Paraffin, IHC - Frozen, Western blot, Functional Assay
Unconjugated

Details

Human GDF9 / GDF-9
Mouse
Human, Monkey, Bat, Dog (tested or 100% immunogen sequence identity)
Mouse, Rat, Bovine, Goat, Hamster, Horse, Pig, Rabbit, Sheep, Chicken (at least 90% immunogen sequence identity)
IgG Monoclonal [mAb-GDF9-53]
Unconjugated
Protein G purified
Unmodified

Applications

  • IHC - Paraffin (1:25 - 1:100)
  • IHC - Frozen
  • Western blot (1:100 - 1:1000)
  • Functional Assay

Specificity and Use

GDF9 / GDF-9 antibody was raised against tuberculin coupled synthetic peptide VPAKYSPLSVLTIEPDGSIAYKEYEDMIATKC from near the C-terminal region of mature human GDF9. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Galago, Marmoset, Shrew, Bat, Dog, Armadillo (100%); Ferret, Sheep, Goat, Panda, Cat, Bovine, Pig, Opossum (97%); Mouse, Rat, Hamster, Rabbit, Horse, Turkey, Zebra finch, Chicken (94%); Elephant (90%); Guinea pig, Xenopus (81%).
aa420-451
Recognizes an epitope within the highly conserved EPDG sequence of GDF9 (growth differentiation factor 9), a homodimeric growth factor and member of the TGF-beta superfamily, closely related to bone morphogenetic proteins (BMPs). GDF9 is specifically expressed by oocytes, playing a vital role in ovarian folliculogenesis, normal follicle development, and fertility. GDF9 signals through binding to bone morphogenetic protein type II receptor (BMPRII), and apparent subsequent activation of TGF-beta type I receptor, otherwise known as activin receptor-like kinase-5 (ALK-5). Clone mAb-GDF9-53 recognizes GDF9 with high immuno-affinity, and has been shown to neutralize GDF9 biological activity,. Removal of sodium azide is recommended prior to use in functional assays.

Packaging

PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About GDF9 / GDF-9

O60383 NM_005260 NP_005251.1

GDF9 Antibody, GDF-9 Antibody

Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B.

Western blot

Western blot
GDF9 over expressing lysate probed with Mouse anti-Human GDF9
 

Requested From: United States
Date Requested: 12/8/2016

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