The Immunohistochemistry Antibody Company
|Human (tested or 100% immunogen sequence identity)|
|GCN2 antibody was raised against the epitope recognized maps to a region between residues 1 and 50 of human GCN2 (eIF2AK4, eukaryotic translation initiation factor 2 alpha kinase 4) using the numbering given in entry NP_001013725.2 (GeneID 440275).|
|Recognizes human Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (eIF2AK4, GCN2, General Control Non derepressible 2).|
|Suitable for use in Western Blot and Immunoprecipitation. Western blot: 1:5000-1:15000. Immunoprecipitation: 2-5 ug/ml of lysate.|
|Tris-citrate/phosphate buffer, pH 7-8, 0.09% sodium azide.|
|For research use only.|
EIF2AK4 Antibody, GCN2 Antibody, GCN2 eIF2alpha kinase Antibody, GCN2-like protein Antibody, Mgcn2 Antibody, KIAA1338 AntibodyGCN2 is a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2.