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GAPDH

glyceraldehyde-3-phosphate dehydrogenase

Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.

Gene Name:	glyceraldehyde-3-phosphate dehydrogenase
Synonyms:	GAPDH, A1 40 kd subunit, Activator 1 40 kd subunit, G3PD, GAPD, G3pdh, Rfc40, Rf-c 40 kd subunit
Target Sequences:	NM_002046 NP_002037.2 P04406

Publications (118)

Interference of hepatitis C virus RNA replication by short interfering RNAs. Kapadia SB, Brideau-Andersen A, Chisari FV. Proceedings of the National Academy of Sciences of the United States of America. 2003 100:2014-8. (ICC, WB; Human) [PubMed:12566571] [PMC:PMC149950]

Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration. Akassoglou K, Malester B, Xu J, Tessarollo L, Rosenbluth J, Chao MV. Proceedings of the National Academy of Sciences of the United States of America. 2004 101:5075-80. (ICC, IHC, WB; Mouse) [PubMed:15051870] [PMC:PMC387376]

Prognostic significance of a short sequence insertion in the MCL-1 promoter in chronic lymphocytic leukemia. Moshynska O, Sankaran K, Pahwa P, Saxena A. Journal of the National Cancer Institute. 2004 96:673-82. [PubMed:15126604]

Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes. Gonzalez-Cabrera PJ, Shi T, Yun J, McCune DF, Rorabaugh BR, Perez DM. Endocrinology. 2004 145:5157-67. [PubMed:15297446]

Myocardial cell death and regeneration during progression of cardiac hypertrophy to heart failure. Sarkar S, Chawla-Sarkar M, Young D, Nishiyama K, Rayborn ME, Hollyfield JG, Sen S. The Journal of biological chemistry. 2004 279:52630-42. [PubMed:15385543]

Regulation of endothelial argininosuccinate synthase expression and NO production by an upstream open reading frame. Pendleton LC, Goodwin BL, Solomonson LP, Eichler DC. The Journal of biological chemistry. 2005 280:24252-60. (WB; Bovine) [PubMed:15851478]

The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes. Dusek RL, Getsios S, Chen F, Park JK, Amargo EV, Cryns VL, Green KJ. The Journal of biological chemistry. 2006 281:3614-24. [PubMed:16286477]

Desmoplakin assembly dynamics in four dimensions: multiple phases differentially regulated by intermediate filaments and actin. Godsel LM, Hsieh SN, Amargo EV, Bass AE, Pascoe-McGillicuddy LT, Huen AC, Thorne ME, Gaudry CA, Park JK, Myung K, Goldman RD, Chew TL, Green KJ. The Journal of cell biology. 2005 171:1045-59. [PubMed:16365169] [PMC:PMC2171300]

Mitogen-activated protein kinases control cardiac KChIP2 gene expression. Jia Y, Takimoto K. Circulation research. 2006 98:386-93. [PubMed:16385079] [PMC:PMC1373668]

High-throughput identification of IMCD proteins using LC-MS/MS. Pisitkun T, Bieniek J, Tchapyjnikov D, Wang G, Wu WW, Shen RF, Knepper MA. Physiological genomics. 2006 25:263-76. [PubMed:16449382] [PMC:PMC1436036]

Inhibition of apoptosis by P2Y2 receptor activation: novel pathways for neuronal survival. Arthur DB, Georgi S, Akassoglou K, Insel PA. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 26:3798-804. [PubMed:16597733]

Activation of endoplasmic reticulum stress response during the development of ischemic heart disease. Azfer A, Niu J, Rogers LM, Adamski FM, Kolattukudy PE. American journal of physiology. Heart and circulatory physiology. 2006 291:H1411-20. [PubMed:16617122] [PMC:PMC1575464]

Lyn kinase promotes erythroblast expansion and late-stage development. Karur VG, Lowell CA, Besmer P, Agosti V, Wojchowski DM. Blood. 2006 108:1524-32. [PubMed:16705093] [PMC:PMC1895506]

Phosphorylation of focal adhesion kinase (FAK) on Ser732 is induced by rho-dependent kinase and is essential for proline-rich tyrosine kinase-2-mediated phosphorylation of FAK on Tyr407 in response to vascular endothelial growth factor. Le Boeuf F, Houle F, Sussman M, Huot J. Molecular biology of the cell. 2006 17:3508-20. [PubMed:16760434] [PMC:PMC1525237]

Heat-killed BCG induces biphasic cyclooxygenase 2+ splenic macrophage formation--role of IL-10 and bone marrow precursors. Shibata Y, Gabbard J, Yamashita M, Tsuji S, Smith M, Nishiyama A, Henriksen RA, Myrvik QN. Journal of leukocyte biology. 2006 80:590-8. [PubMed:16822852]

Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy. Kanadia RN, Shin J, Yuan Y, Beattie SG, Wheeler TM, Thornton CA, Swanson MS. Proceedings of the National Academy of Sciences of the United States of America. 2006 103:11748-53. [PubMed:16864772] [PMC:PMC1544241]

Pluronic L81 enhances triacylglycerol accumulation in the cytosol and inhibits chylomicron secretion. Fatma S, Yakubov R, Anwar K, Hussain MM. Journal of lipid research. 2006 47:2422-32. [PubMed:16894241]

The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF-kappaB pathway. Dell'Eva R, Ambrosini C, Minghelli S, Noonan DM, Albini A, Ferrari N. Carcinogenesis. 2007 28:404-13. [PubMed:16952909]

NAD(P)H oxidases regulate HIF-2alpha protein expression. Block K, Gorin Y, Hoover P, Williams P, Chelmicki T, Clark RA, Yoneda T, Abboud HE. The Journal of biological chemistry. 2007 282:8019-26. [PubMed:17200123]

Apoptotic surge of potassium currents is mediated by p38 phosphorylation of Kv2.1. Redman PT, He K, Hartnett KA, Jefferson BS, Hu L, Rosenberg PA, Levitan ES, Aizenman E. Proceedings of the National Academy of Sciences of the United States of America. 2007 104:3568-73. [PubMed:17360683] [PMC:PMC1805571]

Restoration of tissue factor pathway inhibitor-2 in a human glioblastoma cell line triggers caspase-mediated pathway and apoptosis. George J, Gondi CS, Dinh DH, Gujrati M, Rao JS. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 13:3507-17. [PubMed:17575213] [PMC:PMC1905856]

A ferritin-responsive internal ribosome entry site regulates folate metabolism. Woeller CF, Fox JT, Perry C, Stover PJ. The Journal of biological chemistry. 2007 282:29927-35. [PubMed:17702748]

CD200 and its receptor, CD200R, modulate bone mass via the differentiation of osteoclasts. Cui W, Cuartas E, Ke J, Zhang Q, Einarsson HB, Sedgwick JD, Li J, Vignery A. Proceedings of the National Academy of Sciences of the United States of America. 2007 104:14436-41. [PubMed:17726108] [PMC:PMC1955461]

Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells. Cheng G, Shao Z, Chaudhari B, Agrawal DK. American journal of physiology. Lung cellular and molecular physiology. 2007 293:L1339-47. [PubMed:17873007]

Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel. Shen L, Kondo Y, Ahmed S, Boumber Y, Konishi K, Guo Y, Chen X, Vilaythong JN, Issa JP. Cancer research. 2007 67:11335-43. [PubMed:18056460]

PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells. Chen K, Tu Y, Zhang Y, Blair HC, Zhang L, Wu C. The Journal of biological chemistry. 2008 283:2508-17. [PubMed:18063582]

Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice. Zhang QS, Eaton L, Snyder ER, Houghtaling S, Mitchell JB, Finegold M, Van Waes C, Grompe M. Cancer research. 2008 68:1601-8. [PubMed:18316625]

Signaling pathways modulated by fish oil in salt-sensitive hypertension. Diaz Encarnacion MM, Warner GM, Gray CE, Cheng J, Keryakos HK, Nath KA, Grande JP. American journal of physiology. Renal physiology. 2008 294:F1323-35. [PubMed:18385269] [PMC:PMC2879056]

Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly. Bass-Zubek AE, Hobbs RP, Amargo EV, Garcia NJ, Hsieh SN, Chen X, Wahl JK, Denning MF, Green KJ. The Journal of cell biology. 2008 181:605-13. [PubMed:18474624] [PMC:PMC2386101]

Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer. Chetty C, Lakka SS, Bhoopathi P, Kunigal S, Geiss R, Rao JS. Cancer research. 2008 68:4736-45. [PubMed:18559520] [PMC:PMC2586602]

IL-1beta-driven ST2L expression promotes maturation resistance in rapamycin-conditioned dendritic cells. Turnquist HR, Sumpter TL, Tsung A, Zahorchak AF, Nakao A, Nau GJ, Liew FY, Geller DA, Thomson AW. Journal of immunology (Baltimore, Md. : 1950). 2008 181:62-72. [PubMed:18566370] [PMC:PMC2796738]

uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180. Smith HW, Marra P, Marshall CJ. The Journal of cell biology. 2008 182:777-90. [PubMed:18725541] [PMC:PMC2518715]

PTEN-deficient cancers depend on PIK3CB. Wee S, Wiederschain D, Maira SM, Loo A, Miller C, deBeaumont R, Stegmeier F, Yao YM, Lengauer C. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:13057-62. [PubMed:18755892] [PMC:PMC2529105]

Glycogen synthase kinase 3beta regulates cell death induced by synthetic triterpenoids. Ven R, Larghero P, Arena G, Sporn MB, Albini A, Tosetti F. Cancer research. 2008 68:6987-96. [PubMed:18757413]

AIF-1 expression regulates endothelial cell activation, signal transduction, and vasculogenesis. Tian Y, Jain S, Kelemen SE, Autieri MV. American journal of physiology. Cell physiology. 2009 296:C256-66. [PubMed:18787073] [PMC:PMC2643850]

Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-kappaB and p53 modulation. Monteghirfo S, Tosetti F, Ambrosini C, Stigliani S, Pozzi S, Frassoni F, Fassina G, Soverini S, Albini A, Ferrari N. Molecular cancer therapeutics. 2008 7:2692-702. [PubMed:18790751]

Zag expression during aging suppresses proliferation after kidney injury. Schmitt R, Marlier A, Cantley LG. Journal of the American Society of Nephrology : JASN. 2008 19:2375-83. [PubMed:18815245] [PMC:PMC2588107]

Elucidating the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and retinal transplantation. Vugler A, Carr AJ, Lawrence J, Chen LL, Burrell K, Wright A, Lundh P, Semo M, Ahmado A, Gias C, da Cruz L, Moore H, Andrews P, Walsh J, Coffey P. Experimental neurology. 2008 214:347-61. [PubMed:18926821] Related Antibodies: LS-C20161.

Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism. MacFarlane AJ, Perry CA, Girnary HH, Gao D, Allen RH, Stabler SP, Shane B, Stover PJ. The Journal of biological chemistry. 2009 284:1533-9. [PubMed:19033438] [PMC:PMC2615521]

The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. Woodruff TM, Costantini KJ, Crane JW, Atkin JD, Monk PN, Taylor SM, Noakes PG. Journal of immunology (Baltimore, Md. : 1950). 2008 181:8727-34. [PubMed:19050293]

PARP-1 inhibits glycolysis in ischemic kidneys. Devalaraja-Narashimha K, Padanilam BJ. Journal of the American Society of Nephrology : JASN. 2009 20:95-103. [PubMed:19056868] [PMC:PMC2615730]

Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay. Carr AJ, Vugler A, Lawrence J, Chen LL, Ahmado A, Chen FK, Semo M, Gias C, da Cruz L, Moore HD, Walsh J, Coffey PJ. Molecular vision. 2009 15:283-95. [PubMed:19204785] [PMC:PMC2635847] Related Antibodies: LS-C20161.

Repression of BIRC5/survivin by FOXO3/FKHRL1 sensitizes human neuroblastoma cells to DNA damage-induced apoptosis. Obexer P, Hagenbuchner J, Unterkircher T, Sachsenmaier N, Seifarth C, Bck G, Porto V, Geiger K, Ausserlechner M. Molecular biology of the cell. 2009 20:2041-8. [PubMed:19211844] [PMC:PMC2663932]

Interleukin-13-induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells. Zhao J, Maskrey B, Balzar S, Chibana K, Mustovich A, Hu H, Trudeau JB, O'Donnell V, Wenzel SE. American journal of respiratory and critical care medicine. 2009 179:782-90. [PubMed:19218191] [PMC:PMC2675565]

OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. Hynynen R, Suchanek M, Spandl J, Bck N, Thiele C, Olkkonen VM. Journal of lipid research. 2009 50:1305-15. [PubMed:19224871] [PMC:PMC2694330]

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species. Sudarshan S, Sourbier C, Kong HS, Block K, Valera Romero VA, Yang Y, Galindo C, Mollapour M, Scroggins B, Goode N, Lee MJ, Gourlay CW, Trepel J, Linehan WM, Neckers L. Molecular and cellular biology. 2009 29:4080-90. [PubMed:19470762] [PMC:PMC2715796]

Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production. Guerreiro JR, Lameu C, Oliveira EF, Klitzke CF, Melo RL, Linares E, Augusto O, Fox JW, Lebrun I, Serrano SM, Camargo AC. The Journal of biological chemistry. 2009 284:20022-33. [PubMed:19491403] [PMC:PMC2740428]

Intravesical combination treatment with antisense oligonucleotides targeting heat shock protein-27 and HTI-286 as a novel strategy for high-grade bladder cancer. Matsui Y, Hadaschik BA, Fazli L, Andersen RJ, Gleave ME, So AI. Molecular cancer therapeutics. 2009 8:2402-11. [PubMed:19625496]

Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats. Kim JH, Bugaj LJ, Oh YJ, Bivalacqua TJ, Ryoo S, Soucy KG, Santhanam L, Webb A, Camara A, Sikka G, Nyhan D, Shoukas AA, Ilies M, Christianson DW, Champion HC, Berkowitz DE. Journal of applied physiology (Bethesda, Md. : 1985). 2009 107:1249-57. [PubMed:19661445] [PMC:PMC2763842]

The proteasome is an integral part of solar ultraviolet a radiation-induced gene expression. Catalgol B, Ziaja I, Breusing N, Jung T, Hhn A, Alpertunga B, Schroeder P, Chondrogianni N, Gonos ES, Petropoulos I, Friguet B, Klotz LO, Krutmann J, Grune T. The Journal of biological chemistry. 2009 284:30076-86. [PubMed:19690165] [PMC:PMC2781562]

Correlation of human leukocyte antigen-G (HLA-G) expression and disease progression in epithelial ovarian cancer. Jung YW, Kim YT, Kim SW, Kim S, Kim JH, Cho NH, Kim JW. Reproductive sciences (Thousand Oaks, Calif.). 2009 16:1103-11. [PubMed:19692629]

Mechanism of the internal ribosome entry site-mediated translation of serine hydroxymethyltransferase 1. Fox JT, Stover PJ. The Journal of biological chemistry. 2009 284:31085-96. [PubMed:19734143] [PMC:PMC2781508]

A UV-responsive internal ribosome entry site enhances serine hydroxymethyltransferase 1 expression for DNA damage repair. Fox JT, Shin WK, Caudill MA, Stover PJ. The Journal of biological chemistry. 2009 284:31097-108. [PubMed:19734144] [PMC:PMC2781509]

Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4. Kolosionek E, Savai R, Ghofrani HA, Weissmann N, Guenther A, Grimminger F, Seeger W, Banat GA, Schermuly RT, Pullamsetti SS. Molecular biology of the cell. 2009 20:4751-65. [PubMed:19759179] [PMC:PMC2777105]

Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling. Zhao J, Zhang Y, Ithychanda SS, Tu Y, Chen K, Qin J, Wu C. The Journal of biological chemistry. 2009 284:34308-20. [PubMed:19833732] [PMC:PMC2797199]

Clathrin-independent internalization of normal cellular prion protein in neuroblastoma cells is associated with the Arf6 pathway. Kang YS, Zhao X, Lovaas J, Eisenberg E, Greene LE. Journal of cell science. 2009 122:4062-9. [PubMed:19843586] [PMC:PMC2798124]

Role of androgens and the androgen receptor in epithelial-mesenchymal transition and invasion of prostate cancer cells. Zhu ML, Kyprianou N. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010 24:769-77. [PubMed:19901020] [PMC:PMC2830130]

NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts. Bondi CD, Manickam N, Lee DY, Block K, Gorin Y, Abboud HE, Barnes JL. Journal of the American Society of Nephrology : JASN. 2010 21:93-102. (WB; Rat) [PubMed:19926889] [PMC:PMC2799274]

NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase. Dynia DW, Steinmetz AG, Kocinsky HS. American journal of physiology. Renal physiology. 2010 298:F745-53. [PubMed:20015946] [PMC:PMC2838583]

Regulation of vascular endothelial growth factor-induced endothelial cell migration by LIM kinase 1-mediated phosphorylation of annexin 1. Ct MC, Lavoie JR, Houle F, Poirier A, Rousseau S, Huot J. The Journal of biological chemistry. 2010 285:8013-21. (WB; Human) [PubMed:20061392] [PMC:PMC2832952]

Group I p21-activated kinases regulate thyroid cancer cell migration and are overexpressed and activated in thyroid cancer invasion. McCarty SK, Saji M, Zhang X, Jarjoura D, Fusco A, Vasko VV, Ringel MD. Endocrine-related cancer. 2010 17:989-99. [PubMed:20817787]

microRNA-92a promotes lymph node metastasis of human esophageal squamous cell carcinoma via E-cadherin. Chen ZL, Zhao XH, Wang JW, Li BZ, Wang Z, Sun J, Tan FW, Ding DP, Xu XH, Zhou F, Tan XG, Hang J, Shi SS, Feng XL, He J. The Journal of biological chemistry. 2011 286:10725-34. (WB) [PubMed:21148309] [PMC:PMC3060523]

Transcription factor Stat5 knockdown enhances androgen receptor degradation and delays castration-resistant prostate cancer progression in vivo. Thomas C, Zoubeidi A, Kuruma H, Fazli L, Lamoureux F, Beraldi E, Monia BP, MacLeod AR, Throff JW, Gleave ME. Molecular cancer therapeutics. 2011 10:347-59. (WB; Human) [PubMed:21216933]

p53 target Siva regulates apoptosis in ischemic kidneys. Singaravelu K, Padanilam BJ. American journal of physiology. Renal physiology. 2011 300:F1130-41. [PubMed:21307125] [PMC:PMC3094050]

Latent membrane protein 1 of Epstein-Barr virus regulates death-associated protein kinase 1 in lymphoblastoid cell line. Lee CW, Leu SJ, Tzeng RY, Wang SF, Tsai SC, Sun KH, Chen RH, Huang JC. Virology. 2011 413:19-25. [PubMed:21353277]

Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling. Tian X, Vroom C, Ghofrani HA, Weissmann N, Bieniek E, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS. PloS one. 2011 6:e18136. (WB; Rat) [PubMed:21494592] [PMC:PMC3073929]

Endogenic regulation of proliferation and zinc transporters by pigment epithelial cells nonvirally transfected with PEDF. Johnen S, Kazanskaya O, Armogan N, Stickelmann C, Stcker M, Walter P, Thumann G. Investigative ophthalmology & visual science. 2011 52:5400-7. (WB; Rabbit) [PubMed:21508100]

RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, Paszkowski-Rogacz M, Matarese F, Janssen-Megens EM, Hubner NC, Schulz H, de Vries I, Ding L, Huebner N, Mann M, Stunnenberg HG, Buchholz F. PloS one. 2011 6:e19470. [PubMed:21589869] [PMC:PMC3093395]

Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis. Marcotte R, Smith HW, Sanguin-Gendreau V, McDonough RV, Muller WJ. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:2808-13. [PubMed:21628573] [PMC:PMC3286961]

The expression of retinal cell markers in human retinal pigment epithelial cells and their augmentation by the synthetic retinoid fenretinide. Carr AJ, Vugler AA, Yu L, Semo M, Coffey P, Moss SE, Greenwood J. Molecular vision. 2011 17:1701-15. [PubMed:21738400] [PMC:PMC3130725] Related Antibodies: LS-C20161.

Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein. Lee JW, Liao PC, Young KC, Chang CL, Chen SS, Chang TT, Lai MD, Wang SW. Journal of proteome research. 2011 10:4522-34. (WB; Human) [PubMed:21823664]

Upregulation of cellular Bcl-2 by the KSHV encoded RTA promotes virion production. Gao J, Cai Q, Lu J, Jha HC, Robertson ES. PloS one. 2011 6:e23892. [PubMed:21901143] [PMC:PMC3162012]

Integrin 91-mediated cell migration in glioblastoma via SSAT and Kir4.2 potassium channel pathway. Veeravalli KK, Ponnala S, Chetty C, Tsung AJ, Gujrati M, Rao JS. Cellular signalling. 2012 24:272-81. [PubMed:21946432] [PMC:PMC3205329]

Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-B leads to hyperbilirubinemia. Fujiwara R, Chen S, Karin M, Tukey RH. Gastroenterology. 2012 142:109-118.e2. (WB; Mouse) [PubMed:21983082] [PMC:PMC3428231]

Regulation of neuroendocrine differentiation by AKT/hnRNPK/AR/-catenin signaling in prostate cancer cells. Ciarlo M, Benelli R, Barbieri O, Minghelli S, Barboro P, Balbi C, Ferrari N. International journal of cancer. Journal international du cancer. 2012 131:582-90. (WB; Human) [PubMed:22015967]

Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo. Rosborough BR, Castellaneta A, Natarajan S, Thomson AW, Turnquist HR. Journal of leukocyte biology. 2012 91:701-9. [PubMed:22028329]

Cell-cell contact preserves cell viability via plakoglobin. Wei Q, Hariharan V, Huang H. PloS one. 2011 6:e27064. [PubMed:22046445] [PMC:PMC3203941]

Mycobacterium bovis bacilli Calmette-Guerin regulates leukocyte recruitment by modulating alveolar inflammatory responses. Andersson M, Lutay N, Hallgren O, Westergren-Thorsson G, Svensson M, Godaly G. Innate immunity. 2012 18:531-40. (WB; Human) [PubMed:22058091] [PMC:PMC3548393]

Thin-filament length correlates with fiber type in human skeletal muscle. Gokhin DS, Kim NE, Lewis SA, Hoenecke HR, D'Lima DD, Fowler VM. American journal of physiology. Cell physiology. 2012 302:C555-65. [PubMed:22075691] [PMC:PMC3287155]

Identification of potential markers related to neoadjuvant chemotherapy sensitivity of breast cancer by SELDI-TOF MS. Zhang K, Yuan K, Wu H, Li Q, Wang Y, Chen S, Zhang L, Gu H, Fu R. Applied biochemistry and biotechnology. 2012 166:753-63. (WB; Human) [PubMed:22127810]

Curcumin protects against thioacetamide-induced hepatic fibrosis by attenuating the inflammatory response and inducing apoptosis of damaged hepatocytes. Wang ME, Chen YC, Chen IS, Hsieh SC, Chen SS, Chiu CH. The Journal of nutritional biochemistry. 2012 23:1352-66. [PubMed:22221674]

Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome. Hoeffer CA, Sanchez E, Hagerman RJ, Mu Y, Nguyen DV, Wong H, Whelan AM, Zukin RS, Klann E, Tassone F. Genes, brain, and behavior. 2012 11:332-41. [PubMed:22268788] [PMC:PMC3319643]

A high calcium diet containing nonfat dry milk reduces weight gain and associated adipose tissue inflammation in diet-induced obese mice when compared to high calcium alone. Thomas AP, Dunn TN, Drayton JB, Oort PJ, Adams SH. Nutrition & metabolism. 2012 9:3. (WB; Mouse) [PubMed:22269778] [PMC:PMC3284427]

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Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway. Twigger K, Roulstone V, Kyula J, Karapanagiotou EM, Syrigos KN, Morgan R, White C, Bhide S, Nuovo G, Coffey M, Thompson B, Jebar A, Errington F, Melcher AA, Vile RG, Pandha HS, Harrington KJ. BMC cancer. 2012 12:368. (WB; Human) [PubMed:22920673] [PMC:PMC3537694]

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Tmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lens. Gokhin DS, Nowak RB, Kim NE, Arnett EE, Chen AC, Sah RL, Clark JI, Fowler VM. PloS one. 2012 7:e48734. (WB; Mouse) [PubMed:23144950] [PMC:PMC3492431]

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Differential expression of the pro-natriuretic peptide convertases corin and furin in experimental heart failure and atrial fibrosis. Ichiki T, Boerrigter G, Huntley BK, Sangaralingham SJ, McKie PM, Harty GJ, Harders GE, Burnett JC. American journal of physiology. Regulatory, integrative and comparative physiology. 2013 304:R102-9. (WB; Dog, Human) [PubMed:23152112] [PMC:PMC3543660]

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The six amino acid antimicrobial peptide bLFcin6 penetrates cells and delivers siRNA. Fang B, Guo HY, Zhang M, Jiang L, Ren FZ. The FEBS journal. 2013 280:1007-17. (WB; Human) [PubMed:23241223]

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Shared and Cell Type-Specific Mitochondrial Defects and Metabolic Adaptations in Primary Cells from PINK1-Deficient Mice. Kuorilehto T, Ekholm E, Nissinen M, Hietaniemi K, Hiltunen A, Paavolainen P, Penttinen R, Peltonen J. Neuro-degenerative diseases. 2012 [PubMed:23295771]

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Classic swine fever virus NS2 protein leads to the induction of cell cycle arrest at S-phase and endoplasmic reticulum stress. Tang QH, Zhang YM, Fan L, Tong G, He L, Dai C. Virology journal. 2010 7:4. (ICC; Pig) [Full Text Article] [PubMed:20064240] [PMC:PMC2819037]

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Airway hyperresponsiveness induced by repeated esophageal infusion of HCl in guinea pigs. Cheng YM, Cao AL, Zheng JP, Wang HW, Sun YS, Liu CF, Zhang BB, Wang Y, Zhu SL, Wu DZ. American journal of respiratory cell and molecular biology. 2014 51:701-8. (WB; Human) [Full Text Article] [PubMed:24828018]

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Atgl deficiency induces podocyte apoptosis and leads to glomerular filtration barrier damage. Chen W, Jiang Y, Han J, Hu J, He T, Yan T, Huang N, Zhang Q, Mei H, Liao Y, Huang Y, Chen B. The FEBS journal. 2017 April;284:1070-1081. [Full Text Article] [PubMed:28194887] Related Antibodies: LS-C36500.

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Xanthine oxidase inhibition prevents atrial fibrillation in a canine model of atrial pacing-induced left ventricular dysfunction. Masao Sakabe, Akira Fujiki, Tamotsu Sakamoto, Yosuke Nakatani, Koichi Mizumaki, Hiroshi Inoue. Journal of cardiovascular electrophysiology. 2012 October;23:1130-5. [Full Text Article] [PubMed:22587612]

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