Chicken GAP43

Mouse

Chicken (tested or 100% immunogen sequence identity)

IgM Monoclonal

2G13

Unconjugated

Supernatant

Embryonic chick tectal membranes.

Recognizes a protein originally termed 2G13P which is localized to growth cones. Subsequent investigation has identified this protein to be 40S ribosomal protein SA, also known as 37 kD laminin receptor precursor or Laminin receptor 1. 40S ribosomal protein SA is a 296 amino acid ~37kD membrane, cytoplasmic and nuclear protein required for the assembly and/or stability of the 40S ribosomal subunit. In vertebrate evolution the molecule has acquired a secondary function as a laminin receptor. In growth cones expression is notable particularly in filopodia and lamellipodia in developing rat CNS and embryonic neurons in culture. 40S ribosomal protein SA interacts with the filamentous actin cytoskeleton and therefore may be involved in growth cone motility. Has been used for the detection of growth cones by immunohistochemistry and identification of 40S ribosomal protein SA by western blotting in chicken and rat samples.

• IHC - Paraffin
• IHC - Frozen

Immunohistology: This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.

0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P17677 NCBI: NM_002045 NP_002036.1