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GAP43

growth associated protein 43

This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

Gene Name:	growth associated protein 43
Family/Subfamily:	Neuromodulin , Not assigned-Other
Synonyms:	GAP43, Axonal membrane protein GAP-43, B-50, Growth associated protein 43, Growth-associated protein 43, Neural phosphoprotein B-50, Neuromodulin, PP46, GAP-43, Protein F1
Target Sequences:	NM_002045 NP_002036.1 P17677

Publications (15)

Axonal regeneration into acellular nerve grafts is enhanced by degradation of chondroitin sulfate proteoglycan. Krekoski CA, Neubauer D, Zuo J, Muir D. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 21:6206-13. [PubMed:11487643]

Regeneration of axons after nerve transection repair is enhanced by degradation of chondroitin sulfate proteoglycan. Zuo J, Neubauer D, Graham J, Krekoski CA, Ferguson TA, Muir D. Experimental neurology. 2002 176:221-8. [PubMed:12093099]

Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma. Berwanger B, Hartmann O, Bergmann E, Bernard S, Nielsen D, Krause M, Kartal A, Flynn D, Wiedemeyer R, Schwab M, Schfer H, Christiansen H, Eilers M. Cancer cell. 2002 2:377-86. [PubMed:12450793]

Metalloproteinase-dependent predegeneration in vitro enhances axonal regeneration within acellular peripheral nerve grafts. Krekoski CA, Neubauer D, Graham JB, Muir D. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 22:10408-15. [PubMed:12451140]

Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation. Teo JL, Ma H, Nguyen C, Lam C, Kahn M. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:12171-6. [PubMed:16093313] [PMC:PMC1189325]

Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system. Osterfield M, Egelund R, Young LM, Flanagan JG. Development (Cambridge, England). 2008 135:1189-99. [PubMed:18272596]

Wnt/Frizzled family members mediate olfactory sensory neuron axon extension. Rodriguez-Gil DJ, Greer CA. The Journal of comparative neurology. 2008 511:301-17. (IHC; Mouse) [PubMed:18803244] [PMC:PMC2570497]

Composition of the migratory mass during development of the olfactory nerve. Miller AM, Treloar HB, Greer CA. The Journal of comparative neurology. 2010 518:4825-41. [PubMed:21031554]

Renal cystic disease proteins play critical roles in the organization of the olfactory epithelium. Pluznick JL, Rodriguez-Gil DJ, Hull M, Mistry K, Gattone V, Johnson CA, Weatherbee S, Greer CA, Caplan MJ. PloS one. 2011 6:e19694. (ICC, IHC, IHC-Fr; Mouse, Rat) [PubMed:21614130] [PMC:PMC3094399]

Impaired sprouting and axonal atrophy in cerebellar climbing fibres following in vivo silencing of the growth-associated protein GAP-43. Grasselli G, Mandolesi G, Strata P, Cesare P. PloS one. 2011 6:e20791. [PubMed:21695168] [PMC:PMC3112224]

Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription. Murakami M, Ito H, Hagiwara K, Kobayashi M, Hoshikawa A, Takagi A, Kojima T, Tamiya-Koizumi K, Sobue S, Ichihara M, Suzuki M, Banno Y, Nozawa Y, Murate T. Journal of cellular biochemistry. 2011 112:3449-58. (WB; Human) [PubMed:21769916]

Fas-associated factor 1 as a regulator of olfactory axon guidance. Cheng K, Bai L, Belluscio L. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:11905-13. [PubMed:21849551] [PMC:PMC3184845]

In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function. Cheng N, Cai H, Belluscio L. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:13699-704. [PubMed:21957232] [PMC:PMC3190161]

IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses. Ray A, Treloar HB. Molecular and cellular neurosciences. 2012 50:238-49. (ICC, IHC; Mouse) [PubMed:22687584] [PMC:PMC3418437]

Critical role of GFR1 in the development and function of the main olfactory system. Marks C, Belluscio L, Ibez CF. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:17306-20. (ICC, IHC; Mouse) [PubMed:23197722]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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