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GALR2 / Galanin Receptor 2

galanin receptor 2

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.

Gene Name: galanin receptor 2
Family/Subfamily: GPCR , Galanin
Synonyms: GALR2, Galanin-2 receptor, Gal-2 receptor, Galanin receptor type 2, GALNR2, GALR-2, Gal receptor 2, GAL subtype 2 receptor, Gal-r2, Galanin r2 receptor, GAL2-R, Galanin receptor 2, Galanin receptor subtype 2
Target Sequences: NM_003857 NP_003848.1 O43603

Publications (2)

1
Neuropeptides Profile and Increased Innervation in Becker's Nevus. Ji Seok Kim, Myeong Jin Park, Hye Young Kang, Seung Phil Hong, Byung Cheol Park, Myung Hwa Kim. Annals of dermatology. 2019 Apr;;31:154-163. [Full Text Article] [PubMed:33911564] [PMC:PMC7992669] Related Antibodies: LS-B4081.
2
Activation of Galanin Receptor 1 with M617 Attenuates Neuronal Apoptosis via ERK/GSK-3ß/TIP60 Pathway After Subarachnoid Hemorrhage in Rats. Hui Shi, Yuanjian Fang, Lei Huang, Ling Gao, Cameron Lenahan, Takeshi Okada, Zachary D Travis, Shucai Xie, Hong Tang, Qin Lu, Rui Liu, Jiping Tang, Yuan Cheng, John H Zhang. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2021 July;18:1905-1921. [Full Text Article] [PubMed:34086200] [PMC:PMC8609084] Related Antibodies: LS-C805729.

☰ Filters
Antibodies (18)
ELISA Kits (4)
Custom (2)
Primary (18)
Sandwich (2)
GALR2 / Galanin Receptor 2 (22)
Human (19)
Mouse (11)
Rat (11)
Bovine (2)
Chicken (1)
Dog (1)
Hamster (1)
Horse (1)
Monkey (1)
IHC (6)
IHC-P (4)
WB (14)
ELISA (4)
IF (1)
Peptide-ELISA (4)
rabbit (17)
goat (1)
Product Group
GPCR Database Antibodies (2)
IHCPlus (1)
PathPlus Neuro (2)
IgG (8)
polyclonal pc (18)
96-Well Strip Plate (4)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (15)
C-Terminus (5)
180-260 aa, Internal (1)
Internal (1)
Transmembrane Domain (1)
aa128-141 (1)
aa189-238 (1)
aa201-250 (1)
aa243-336 (1)
No (20)
Yes (2)
Plasma (2)
Serum (2)
GALR2 / Galanin Receptor 2 Antibody - Anti-GALR2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
GALR2 / Galanin Receptor 2 Antibody - Anti-GALR2 / Galanin Receptor 2 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
Fast Shipping
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (Transmembrane Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
GALR2 / Galanin Receptor 2 Antibody - Staining RAW264.7 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
GALR2 / Galanin Receptor 2 Antibody - Anti-GALR2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
Fast Shipping
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
GALR2 / Galanin Receptor 2 Antibody - Western blot analysis of lysates from RAW264.7 cells, using GALR2 Antibody. The lane on the right is blocked with the synthesized peptide.
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GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (aa201-250) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
GALR2 / Galanin Receptor 2 Antibody - Galanin Receptor 2 antibody detects GALR2 protein at membrane on Cal27 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded Cal27 xenograft. Galanin Receptor 2 antibody dilution:1:500.
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GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (aa243-336) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
GALR2 / Galanin Receptor 2 Antibody - Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue  using GALR2 Polyclonal Antibody at dilution of 1:40(×200)
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GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
GALR2 / Galanin Receptor 2 Antibody - Immunohistochemistry of paraffin-embedded Human cervical cancer tissue  using GALR2 Polyclonal Antibody at dilution of 1:25(×200)
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GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (180-260 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
GALR2 / Galanin Receptor 2 Antibody - Western blot analysis of extracts from RAW264.7 cells, using GALR2 antibody.
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GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
GALR2 / Galanin Receptor 2 Antibody - Western blot analysis of the lysates from HepG2 cells using GALR2 antibody.
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GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (aa189-238) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
GALR2 / Galanin Receptor 2 Antibody - Antibody (0.3 ug/ml) staining of Human Heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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GALR2 / Galanin Receptor 2 Goat anti-Human Polyclonal (aa128-141) Antibody
Chicken, Bovine, Mouse, Dog, Rat, Hamster, Horse, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
GALR2 / Galanin Receptor 2 Antibody - GALR2 antibody Western blot of A549 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
GALR2 / Galanin Receptor 2 Antibody - GALR2 antibody Western blot of A549 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$469
GALR2 / Galanin Receptor 2 Antibody - GALR2 antibody Western blot of A549 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$469
GALR2 / Galanin Receptor 2 Antibody - GALR2 antibody Western blot of A549 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$469
GALR2 / Galanin Receptor 2 Antibody - Western blot analysis of GALR2 expression in mouse brain (A); rat brain (B) whole cell lysates.
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GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$321
GALR2 / Galanin Receptor 2 Antibody - Western blot analysis of GALR2 expression in A431 (A) whole cell lysates.
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GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Bovine, Human
WB
Unconjugated
100 µl/$299
GALR2 / Galanin Receptor 2 ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
1 Plate/$783
GALR2 / Galanin Receptor 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
GALR2 / Galanin Receptor 2 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
1 Plate/$783
GALR2 / Galanin Receptor 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Viewing 1-22 of 22 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).