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GABBR2 / GABA B Receptor 2
gamma-aminobutyric acid (GABA) B receptor, 2
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
| Gene Name: | gamma-aminobutyric acid (GABA) B receptor, 2 |
| Family/Subfamily: | GPCR , GABA(B) |
| Synonyms: | GABBR2, G protein-coupled receptor 51, GABA(B2), GABA-B receptor 2, Gaba-b receptor r2, GABA-BR2, Gabab-receptor subunit 2, GABA(B)R2, GABA-B receptor, R2 subunit, GABA-B-R2, GABAB receptor-2, GPRC3B, Gb2, HRIHFB2099, G-protein coupled receptor 51, GPR51, HG20, GABA B Receptor 2, GABA-B2, GABAB2, GABABR2, Gbr2 |
| Target Sequences: | NM_005458 NP_005449.5 O75899 |
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