Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal to Human GABBR2 / GABA B Receptor 2
Human, Mouse, Rat
IHC, Western blot, Immunoprecipitation, ELISA
GABBR2 / GABA B Receptor 2
Western blot (1:500 - 1:1000)
Specificity and Use
Peptide corresponding to aa 42-54 of the GABABR2 subunit.
Recognizes the GABABR2 subunit. The GABAB receptor is the first discovered G-protein-coupled receptor whose function requires two subunits, R1 and R2, to form a functional receptor. The R1 subunit extracellular domain binds GABA, and the R2 subunit functions in G-protein activation.
Western Blot: A band of approximately 105 kD is detected.
PBS, pH 7.4, 0.02% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.