Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal to Mouse GABBR1 / GABA B Receptor 1
ICC, Western blot
Mouse GABBR1 / GABA B Receptor 1
Mouse, Rat (tested or 100% immunogen sequence identity)
Protein G purified
Specificity and Use
GABBR1 / GABA B Receptor 1 antibody was raised against synthetic peptide (coupled with THG) derived from amino acid sequence 30-47 of mouse GABA B receptor 1b. Only 1 amino acid is different from immunogen derived from human GB1b.
The polyclonal antibody recognizes N-terminus of mouse gamma-aminobutyric acid (GABA) B receptor 1b. GB1b apparent MW ~100 kD.
Western Blotting: Recommended dilution - 2 ug/ml.
PBS, 15 mM sodium azide, pH 7.4
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.