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G6PC / Glucose-6-Phosphatase

glucose-6-phosphatase, catalytic subunit

Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.

Gene Name: glucose-6-phosphatase, catalytic subunit
Synonyms: G6PC, G6Pase-alpha, G6PC1, G-6-Pase, GSD1, Glucose-6-phosphatase alpha, G6Pase, G6PT, Glucose-6-phosphatase, GSD1a
Target Sequences: NM_000151 NP_000142.2 P35575

Publications (1)

1
Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia. Zhang N, Geng T, Wang Z, Zhang R, Cao T, Camporez JP, Cai SY, Liu Y, Dandolo L, Shulman GI, Carmichael GG, Taylor HS, Huang Y. JCI insight. 2018 May;3:pii: 120304. (Mouse) [Full Text Article] [PubMed:29769440] [PMC:PMC6012507]

☰ Filters
Antibodies (14)
ELISA Kits (8)
Proteins (3)
Over-Expression Lysate (2)
Primary (14)
Recombinant (1)
Sandwich (7)
Sandwich CLIA (1)
G6PC / Glucose-6-Phosphatase (25)
Human (16)
Mouse (5)
Rat (5)
IHC (9)
IHC-P (2)
WB (8)
Flo (6)
ELISA (12)
Peptide-ELISA (1)
rabbit (14)
Product Group
IHCPlus (1)
IgG (13)
polyclonal pc (14)
96-Well Microplate (3)
96-Well Strip Plate (5)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (6)
aa123-149 (7)
aa82-117 (1)
No (25)
Cell Lysates (2)
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Tissue Homogenates (6)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
G6PC / Glucose-6-Phosphatase Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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G6PC / Glucose-6-Phosphatase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P
Unconjugated
50 µg/$460
Select
G6PC / Glucose-6-Phosphatase Rabbit anti-Human Polyclonal (aa82-117) (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
G6PC / Glucose-6-Phosphatase Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
G6PC / Glucose-6-Phosphatase Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
Select
G6PC / Glucose-6-Phosphatase Rabbit anti-Human Polyclonal (aa123-149) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
Select
G6PC / Glucose-6-Phosphatase Rabbit anti-Human Polyclonal (aa123-149) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
Select
G6PC / Glucose-6-Phosphatase Rabbit anti-Human Polyclonal (aa123-149) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
Select
G6PC / Glucose-6-Phosphatase Rabbit anti-Human Polyclonal (aa123-149) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
G6PC / Glucose-6-Phosphatase Rabbit anti-Human Polyclonal (aa123-149) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
Select
G6PC / Glucose-6-Phosphatase Rabbit anti-Human Polyclonal (aa123-149) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
G6PC / Glucose-6-Phosphatase Antibody - G6PC Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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G6PC / Glucose-6-Phosphatase Rabbit anti-Human Polyclonal (aa123-149) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
G6PC / Glucose-6-Phosphatase Protein - 12.5% SDS-PAGE of human G6PC stained with Coomassie Blue
Select
Wheat Germ Extract
GST, N-terminus
66.9 kDa
2 µg/$439
G6PC / Glucose-6-Phosphatase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
G6PC / Glucose-6-Phosphatase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$854
G6PC / Glucose-6-Phosphatase Antibody - Western blot analysis of extracts of human liver tissue using G6PC antibody. The lane on the left was treated with blocking peptide.
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G6PC / Glucose-6-Phosphatase Rabbit anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
293T Cells
Myc-DDK (Flag)
40.3 kDa
20 µg/$150
G6PC / Glucose-6-Phosphatase ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
G6PC / Glucose-6-Phosphatase ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
78.125 - 5000 mIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Select
HEK 293 Cells
Myc-DDK (Flag)
40.3 kDa
100 µg/$494
G6PC / Glucose-6-Phosphatase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$893
G6PC / Glucose-6-Phosphatase Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer tissue  using G6PC Polyclonal Antibody at dilution of 1:50(×200)
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G6PC / Glucose-6-Phosphatase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
G6PC / Glucose-6-Phosphatase Antibody - Immunohistochemistry of paraffin-embedded Human cervical cancer tissue  using G6PC Polyclonal Antibody at dilution of 1:70(×200)
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G6PC / Glucose-6-Phosphatase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
G6PC / Glucose-6-Phosphatase ELISA Kit
Select
Sandwich CLIA
96-Well Microplate
Human
13.7 - 10000 pg/ml
Chemiluminescent
Cell Lysates, Tissue Homogenates
1 Plate/$595
G6PC / Glucose-6-Phosphatase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
78.125 - 5000 mIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
G6PC / Glucose-6-Phosphatase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Viewing 1-25 of 25 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).