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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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FZR1 Antibody (N‑Terminus) LS‑C135252
FZR1 antibody LS-C135252 is an unconjugated rabbit polyclonal antibody to FZR1 from human, mouse, rat and other species. Validated for WB.
Catalog
Size
Price
LS-C135252-50
50 µg
Unavailable

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Product Description

FZR1 antibody LS-C135252 is an unconjugated rabbit polyclonal antibody to FZR1 from human, mouse, rat and other species. Validated for WB.
About FZR1
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Q9UM11 NM_016263 NP_057347.2

FZR1 Antibody, CDC20-like 1b Antibody, CDC20-like protein 1 Antibody, FYR Antibody, FZR Antibody, FZR2 Antibody, HCDH Antibody, Fizzy-related protein homolog Antibody, KIAA1242 Antibody, CDC20C Antibody, Cdh1/Hct1 homolog Antibody, HCDH1 Antibody


Specifications

Target
Mouse FZR1
Host
Rabbit
Reactivity
Mouse, Human, Monkey, Rat, Bat (tested or 100% immunogen sequence identity)
Predicted
Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Chicken, Xenopus, Zebrafish (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with Biotin, FITC, HRP.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (0.2 - 1 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
FZR1 antibody was raised against synthetic peptide from N-Terminus of mouse Fzr1 (Q9R1K5, NP_062731). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bat (100%); Galago, Hamster, Elephant, Dog, Bovine, Horse, Pig, Guinea pig (92%); Opossum, Turkey, Zebra finch, Chicken, Xenopus, Frog, Salmon, Zebrafish (91%).
Blocking Peptide
LS-E18460 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C135252. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
N-Terminus
Specificity
Mouse FZR1
Usage
Western Blot: Suggested dilution at 1 ug/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody.
Presentation
Lyophilized from PBS with 2% sucrose
Reconstitution
Distilled water
Storage
Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year); Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Western blot

FZR1 antibody LS-C135252 Western blot of Mouse Heart lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
FZR1 antibody LS-C135252 Western blot of Mouse Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

FZR1 antibody LS-C135252 Western blot of Mouse Heart lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
FZR1 antibody LS-C135252 Western blot of Mouse Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

FZR1 antibody LS-C135252 Western blot of Mouse Heart lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
FZR1 antibody LS-C135252 Western blot of Mouse Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

FZR1 antibody LS-C135252 Western blot of Mouse Heart lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
FZR1 antibody LS-C135252 Western blot of Mouse Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.


Requested From: 
Date Requested: 6/22/2018

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