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Anti-FZD8 / Frizzled 8 Antibody LS-C6922

Ordering

Wt. Vol. Conc. Price
100 µg 1000 µl 0.1 mg/ml $650
Inquire for larger quantities

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Goat Polyclonal (IgG) to Mouse FZD8 / Frizzled 8
Mouse
IHC, Western blot, ELISA
Unconjugated

Details

Mouse FZD8 / Frizzled 8
Goat
Mouse (tested or 100% immunogen sequence identity)
IgG Polyclonal
Immunoaffinity purified

Applications

IHC (10 - 15 µg/ml), Western blot (0.1 - 0.2 µg/ml), ELISA (0.5 - 1 µg/ml)

Specificity and Use

FZD8 / Frizzled 8 antibody was raised against nS0-derived rmFrizzled-8 extracellular Cysteine-Rich Domain (CRD).
Recognizes mouse Frizzled-8 extracellular Cysteine-Rich Domain (CRD). Approximately 5%cross-reactivity with rmFrizzled-9 and less than 1% cross-reactivity with rmFrizzled-1, rmFrizzled-2, rmFrizzled-3, rmFrizzled-4, rmFrizzled-6 and rmFrizzled-7.
Direct ELISA, Western blot, Immunohistochemistry. Direct ELISA: 0.5-1 ug/ml. Western blot: 0.1-0.2 ug/ml with the appropriate secondary reagents to detect mouse Frizzled-8. The detection limit for rmFrizzled-8 is approximately 5 ng/lane under non-reducing and reducing conditions. Immunohistochemistry: 10-15 ug/ml in fixed cells or tissues.

Packaging

Lyophilized from PBS, 5% trehalose.
1,000 µl Reconstitute in 1 ml of Sterile PBS.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About FZD8 / Frizzled 8

Q9H461 NM_031866 NP_114072.1

FZD8 Antibody, Frizzled family receptor 8 Antibody, Frizzled homolog 8 Antibody, FZ-8 Antibody, Fz8 Antibody, Frizzled 8 Antibody, Frizzled-8 Antibody, HFZ8 Antibody

Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.

Requested From: United States
Date Requested: 9/28/2016

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