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FUS / TLS is a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
Gene Name: | fused in sarcoma |
Synonyms: | FUS, 75 kDa DNA-pairing protein, ALS6, CHOP, FUS-CHOP, FUS1, Fused in sarcoma, HnRNP-P2, HNRNPP2, Oncogene TLS, RNA-binding protein FUS, TLS, C/EBP-homologous protein, ETM4, Fus-like protein, Oncogene FUS, POMP75 |
Target Sequences: | NM_004960 NP_004951.1 P35637 |
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