Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Detection of Human and Rat PhosphoFRS2 (Y436) by Western Blot. Western blot shows lysates of MCF- 7 human breast cancer cell line untreated (-) or treated (+) with 100 uM pervanadate (PV) for 10 minutes and PC-12 rat adrenal pheochromocytoma cell line untreated or treated with 100 ng/ml Recombinant Rat beta-NGF for 10 minutes. PVDF membrane was probed with 1 ug/ml of Human/Mouse/Rat PhosphoFRS2 (Y436) Antigen Affinity-purified Polyclonal Antibody, followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody. Bands were detected for Phospho-FRS2 (Y436) at approximately 70-90 kD (as indicated). This experiment was conducted under reducing conditions.
Requested From: United States
Date Requested: 10/27/2016