Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Monkey (at least 90% immunogen sequence identity)
IHC - Paraffin
Specificity and Use
FPR2 / FPRL1 antibody was raised against synthetic peptide EEVSYESAGYTVLR-C from the N-terminus of human FPR2 / FPRL1 (NP_001453.1). Percent identity by BLAST analysis: Human, Gorilla (100%); Chimpanzee, Orangutan, Monkey (93%); Marmoset (86%).
FPRL1, a Chemoattractant Receptor also called Lipoxin A4 Receptor, functions as a component of the inflammatory response. Its stimulation results in neutrophil activation and desensitization of chemokine receptors in monocytes (Le et al., 2000). The receptor is up-regulated by interleukin-1 in normal human synovial fibroblasts.