Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
FOXO1 Antibody, FKHR Antibody, Forkhead in rhabdomyosarcoma Antibody, FOXO1A Antibody, FKH1 Antibody, Forkhead box protein O1 Antibody, Forkhead box protein O1A Antibody, Forkhead box O1 Antibody, Forkhead box o1a Antibody, Forkhead domain protein fkhr Antibody
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass.
(LEFT)Formalin-fixed and paraffin-embedded human brain tissue reacted with FKHR Antibody (Center D469), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. (RIGHT)Flow cytometric of 293 cells using FKHR Antibody (Center D469)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Western blot of FKHR antibody (Center D469) in 293 cell line lysates (35 ug/lane). FKHR (arrow) was detected using the purified antibody.
Requested From: United States
Date Requested: 2/23/2017