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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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FOXO1 / FKHR Antibody (aa242‑655, clone 4H9) LS‑C53353
Antibody
FKHR antibody LS-C53353 is an unconjugated mouse monoclonal antibody to human FKHR (FOXO1).
Catalog
Size
Price
LS-C53353-50
50 µg
Unavailable

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Product Description

FKHR antibody LS-C53353 is an unconjugated mouse monoclonal antibody to human FKHR (FOXO1).
About FOXO1 / FKHR
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Q12778 NM_002015 NP_002006.2

FOXO1 Antibody, FKHR Antibody, Forkhead in rhabdomyosarcoma Antibody, FOXO1A Antibody, FKH1 Antibody, Forkhead box protein O1 Antibody, Forkhead box protein O1A Antibody, Forkhead box O1 Antibody, Forkhead box o1a Antibody, Forkhead domain protein fkhr Antibody


Specifications

Target
Human FOXO1 / FKHR
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [4H9]
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Immunogen
FOXO1 / FKHR antibody was raised against gST fusion protein containing the region encoding aa 242-655 of human FKHR expressed in E. coli.
Epitope
aa242-655
Specificity
human FKHR (ForkHead in Rhabdomyosarcoma), a 70 kD protein which is a member of a subfamily of the forkhead homeotic gene family of transcription factors. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C-terminus of the FKHR protein
Presentation
PBS.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/22/2018

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