FOXA1

forkhead box A1

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.

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Products

Antibodies (80)

Proteins (7)

Type

Over-Expression Lysate (2)

Primary (80)

Recombinant (5)

Target

FOXA1 (87)

Reactivity

Human (78)

Mouse (21)

Rat (11)

Bat (4)

Bovine (7)

Dog (10)

Guinea pig (3)

Hamster (1)

Monkey (7)

Pig (7)

Xenopus (1)

Zebrafish (7)

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Application

IHC (18)

IHC-Fr (4)

IHC-P (34)

WB (59)

Flo (12)

ChrIP (1)

ELISA (16)

ICC (9)

IF (20)

IP (1)

Peptide-ELISA (2)

RNAi (1)

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Host

rabbit (49)

mouse (30)

goat (1)

Product Group

IHCPlus (5)

PathPlus Cancer (3)

PathPlus Cancer Pathology (3)

Isotype

IgG (32)

IgG1 (4)

IgG1,k (11)

IgG2a,k (6)

IgG2b (4)

IgG2b,k (5)

Clonality

monoclonal mc (30)

polyclonal pc (46)

recombinant monoclonal rmc (4)

Clone

1B1 (1)

2D7 (1)

3C1 (1)

4F6 (1)

EP277 (2)

FOXA1/1241 (2)

FOXA1/1512 (2)

FOXA1/1514 (2)

FOXA1/1515 (2)

FOXA1/1518 (2)

FOXA1/1519 (2)

FOXA1/2230R (2)

OTI3A8 (2)

OTI3C1 (2)

rFOXA1/1515 (2)

TS106 (1)

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Format

APC (1)

APC Conjugated (3)

Azide-free (9)

Biotin Conjugated (7)

BSA-free (6)

Carrier-free (4)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (7)

HRP Conjugated (7)

PE Conjugated (3)

Preservative Free (1)

Ready-to-Use (2)

Unconjugated (51)

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Epitope

N-Terminus (8)

aa15-233 (8)

aa270-298 (7)

aa372-472 (4)

aa395-444 (4)

C-Terminus (1)

aa1-473 (1)

aa143-171 (1)

aa253-472 (1)

aa422-472 (1)

aa429-439 (1)

aa7-86 (1)

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Publications

No (87)

Tag

GST, N-terminus (3)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (3)

Purification

Purified (1)

Select

PathPlus™ FOXA1 Antibody (clone 3C1) LS-B6101

Cancer Pathology

Cancer

(5.0) Rating

Antibody:

FOXA1 Mouse anti-Human Monoclonal (3C1) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$485

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FOXA1 Antibody (aa395-444) LS-B946

Antibody:

FOXA1 Rabbit anti-Human Polyclonal (aa395-444) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

Select

FOXA1 Antibody (aa395-444, FITC) LS-C428239

Antibody:

FOXA1 Rabbit anti-Human Polyclonal (aa395-444) (FITC) Antibody

Reactivity:

Zebrafish, Pig, Rat, Mouse, Dog, Guinea pig, Bovine, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• FITC

• Unconjugated
• FITC

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IHC-plus™ FOXA1 Antibody (aa429-439) LS-B3596

(4.0) Rating

Antibody:

FOXA1 Goat anti-Human Polyclonal (aa429-439) Antibody

Reactivity:

Xenopus, Zebrafish, Pig, Rat, Hamster, Mouse, Bovine, Bat, Human, Monkey

Applications:

ChrIP, IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µg/$485

Select

FOXA1 Antibody (clone FOXA1/1512) LS-C761647

Antibody:

FOXA1 Mouse anti-Human Monoclonal (FOXA1/1512) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC-P, WB

Format:

Unconjugated

Price:

20 µg/$371; 100 µg/$574

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FOXA1 Antibody (clone FOXA1/1512, Azide-free, BSA-free) LS-C761648

Antibody:

FOXA1 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (FOXA1/1512) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC-P, WB

Format:

Unconjugated, Azide-free, BSA-free

Price:

100 µg/$574

• Unconjugated
• Unconjugated, Azide-free, BSA-free

• Unconjugated
• Unconjugated, Azide-free, BSA-free

Select

PathPlus™ FOXA1 Antibody (clone 2D7) LS-B6099

Cancer Pathology

Cancer

(5.0) Rating

Antibody:

FOXA1 Mouse anti-Human Monoclonal (2D7) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, RNAi, WB

Format:

Unconjugated

Price:

100 µg/$485

Select

IHC-plus™ FOXA1 Antibody (clone 4F6) LS-B4356

(4.0) Rating

Antibody:

FOXA1 Mouse anti-Human Monoclonal (4F6) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

Select

FOXA1 Antibody (N-Terminus) LS-C80210

Antibody:

FOXA1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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FOXA1 Antibody (N-Terminus, Biotin) LS-C437057

Antibody:

FOXA1 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Zebrafish, Rat, Mouse, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

• Unconjugated
• Biotin

• Unconjugated
• Biotin

Select

FOXA1 Antibody (Preservative Free) LS-C820403

Antibody:

FOXA1 Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody

Reactivity:

Mouse

Applications:

ICC, IF, IHC-P, WB

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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IHC-plus™ FOXA1 Antibody LS-B10085

(4.0) Rating

Antibody:

FOXA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

Select

FOXA1 Antibody (clone 1B1) LS-C133249

Antibody:

FOXA1 Mouse anti-Human Monoclonal (1B1) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$423

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FOXA1 Antibody (clone EP277) LS-C743580

Antibody:

FOXA1 Rabbit anti-Human Monoclonal (EP277) Antibody

Reactivity:

Human

Applications:

IHC-Fr, IHC-P

Format:

Unconjugated

Price:

0.1 ml/$401; 0.5 ml/$594; 1 ml/$975

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FOXA1 Antibody (clone EP277, Ready-to-Use) LS-C743455

Antibody:

FOXA1 Rabbit anti-Human Monoclonal (Ready-to-Use) (EP277) Antibody

Reactivity:

Human

Applications:

IHC-Fr, IHC-P

Format:

Unconjugated, Ready-to-Use

Price:

3 ml/$401; 7 ml/$498; 15 ml/$737

• Unconjugated
• Unconjugated, Ready-to-Use

• Unconjugated
• Unconjugated, Ready-to-Use

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FOXA1 Antibody (clone FOXA1/1241) LS-C761643

Antibody:

FOXA1 Mouse anti-Human Monoclonal (FOXA1/1241) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC-P, WB

Format:

Unconjugated

Price:

20 µg/$371; 100 µg/$574

Select

FOXA1 Antibody (clone FOXA1/1241, Azide-free, BSA-free) LS-C761644

Antibody:

FOXA1 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (FOXA1/1241) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC-P, WB

Format:

Unconjugated, Azide-free, BSA-free

Price:

100 µg/$574

• Unconjugated
• Unconjugated, Azide-free, BSA-free

• Unconjugated
• Unconjugated, Azide-free, BSA-free

Select

FOXA1 Antibody (N-Terminus) LS-C81993

Antibody:

FOXA1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

FOXA1 Antibody (clone FOXA1/1514) LS-C761649

Antibody:

FOXA1 Mouse anti-Human Monoclonal (FOXA1/1514) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC-P, WB

Format:

Unconjugated

Price:

20 µg/$371; 100 µg/$574

Select

FOXA1 Antibody (clone FOXA1/1514, Azide-free, BSA-free) LS-C761650

Antibody:

FOXA1 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (FOXA1/1514) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC-P, WB

Format:

Unconjugated, Azide-free, BSA-free

Price:

100 µg/$574

• Unconjugated
• Unconjugated, Azide-free, BSA-free

• Unconjugated
• Unconjugated, Azide-free, BSA-free

Select

FOXA1 Antibody (aa15-233, Biotin) LS-C688689

Antibody:

FOXA1 Rabbit anti-Human Polyclonal (aa15-233) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

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FOXA1 Antibody (aa7-86) LS-C121215

Antibody:

FOXA1 Mouse anti-Human Monoclonal (aa7-86) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$832

Select

FOXA1 Antibody (Biotin) LS-C526149

Antibody:

FOXA1 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IHC, WB

Format:

Biotin Conjugated

Price:

100 µl/$1,054

• Unconjugated
• Biotin

• Unconjugated
• Biotin

Select

FOXA1 Antibody (clone FOXA1/1518) LS-C761641

Antibody:

FOXA1 Mouse anti-Human Monoclonal (FOXA1/1518) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC-P

Format:

Unconjugated

Price:

20 µg/$371; 100 µg/$574

Select

FOXA1 Antibody (clone FOXA1/1518, Azide-free, BSA-free) LS-C761642

Antibody:

FOXA1 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (FOXA1/1518) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC-P

Format:

Unconjugated, Azide-free, BSA-free

Price:

100 µg/$574

• Unconjugated
• Unconjugated, Azide-free, BSA-free

• Unconjugated
• Unconjugated, Azide-free, BSA-free

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