Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey, Mouse, Bat, Bovine, Dog, Hamster, Horse, Pig
Western blot, ELISA
Human FKBP5 / FKBP51
Human, Monkey, Mouse, Bat, Bovine, Dog, Hamster, Horse, Pig (tested or 100% immunogen sequence identity)
Rat, Rabbit, Chicken (at least 90% immunogen sequence identity)
Western blot (1:1000)
Specificity and Use
FKBP5 / FKBP51 antibody was raised against synthetic peptide corresponding to aa394-407 (CQKKAKEHNERDRR) of human FKBP51 (FK506 binding protein 51). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Tamarin, Mouse, Hamster, Panda, Dog, Bat, Bovine, Horse, Pig, Opossum (100%); Rat, Elephant, Rabbit, Turkey, Chicken (93%); Platypus (86%).
Recognizes human FKBP51. Species cross-reactivity: mouse, rat, hamster and canine.
Suitable for use in ELISA and Western Blot. Western Blot: 1:1000. Detects a band of ~51kD.
PBS, 1 mg/ml BSA, 0.05% sodium azide.
Long term: Add glycerol (40-50%) aliquot and store at -20C; Short term:+4C
FKBP5 Antibody, 51 kd fk506-binding protein Antibody, 51 kDa FK506-binding protein Antibody, 51 kDa FK506-binding protein 5 Antibody, 51 kDa FKBP Antibody, AIG6 Antibody, Androgen-regulated protein 6 Antibody, FKBP-51 Antibody, FKBP-5 Antibody, FKBP51 Antibody, FF1 antigen Antibody, FK506 binding protein 5 Antibody, p54 Antibody, Ptg-10 Antibody, Rotamase Antibody, T-cell FK506-binding protein Antibody, PPIase Antibody, PPIase FKBP5 Antibody, FK506-binding protein 5 Antibody, FKBP54 Antibody, HSP90-binding immunophilin Antibody
FKBP5 / FKBP51 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein.