Virus FIV gp95

Mouse

Virus (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

SU1-30

Unconjugated

Affinity purified

Unmodified

Recognizes the relatively conserved E60 peptide (amino acid sequence SSWKQRNRWEWRPDF) located within the V3 region of FIV (Feline Immunodeficiency Virus) envelope glycoprotein SU, gp95. The primary receptor for FIV infection of cats has been identified as the T-cell activation antigen CD134 which, along with CXC chemokine receptor 4 (CXCR4), facilitates the infection of CD4+ primary target cells, resulting in a depletion in the CD4+ population. Studies have shown that the V3 loop of SU, gp95 is a ma a major immunogenic domain, suggested to contain the main determinants for the binding of FIV SU, gp95 to CXCR4. Clone SU1-30 has been shown to inhibit the sCD134-activated entry of both clade B and clade C FIV strains. Does not recognize Feline Leukaemia Virus, Feline Herpes Virus type 1, Feline Coronavirus or Feline Calicivirus. Removal of Sodium Azide is recommended prior to use in functional studies.

• Western blot
• Flow Cytometry

Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Method sheets are available on request.

PBS, 0.05% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

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