Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal (IgG) to Human Fibrin Degradation Product D-Dimer
Mouse Monoclonal [clone DD4] (IgG2b) to Human Fibrin Degradation Product D-Dimer
Western blot, ELISA
Human Fibrin Degradation Product D-Dimer
Human (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [DD4]
Specificity and Use
Homogenized fibrin clot.
Recognizes human D-dimer and shows low cross-reactivity with fibrinogen (D-monomer). D-dimers are the principle degradation products of cross-linked fibrin, released into the bloodstream following the digestion of fibrin clots (thrombus) by the enzyme plasmin, and thus measurement of the level of D-dimer in plasma, can be used as an indication of thrombotic disorders. Can be used as the detection antibody in matched pair ELISA for the detection of D-dimer in human plasma. Plasma samples must be diluted with 10 mM Tris-HCl buffer, pH7.5, containing 1 M NaCl (final concentration in sample >0.5 M) and 0.1% Tween 20.
ELISA: This product may be used in an indirect ELISA or as a detection antibody in a sandwich ELISA together with clone DD1 (product code LS-C58035) or clone DD3 (product code LS-C58036), for the detection of D-dimer in human plasma. Plasma samples must be diluted with 10 mM Tris-HCl buffer, pH7.5, containing 1 M NaCl (final concentration in sample >0.5 M) and 0.1% Tween 20.