FHIT

fragile histidine triad

Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca2+ transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.

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Products

Antibodies (48)

Proteins (10)

ELISA Kits (2)

Type

Cell-Based (1)

Over-Expression Lysate (4)

Primary (48)

Recombinant (6)

Sandwich (1)

Target

FHIT (60)

Reactivity

Human (46)

Mouse (14)

Rat (11)

Guinea pig (3)

Horse (3)

Zebrafish (3)

Application

IHC (27)

IHC-P (10)

WB (36)

ELISA (19)

ICC (4)

IF (11)

Peptide-ELISA (6)

Host

rabbit (37)

mouse (11)

Product Group

IHCPlus (3)

Isotype

IgG (20)

IgG1 (6)

IgG1,k (2)

IgG2a (1)

IgG2b (2)

Clonality

monoclonal mc (11)

polyclonal pc (37)

Clone

1093CT23.1.2 (1)

1C3 (1)

OTI1D7 (2)

OTI2C1 (2)

OTI2C2 (1)

OTI6B4 (2)

Format

96-Well Microplate (1)

96-Well Strip Plate (1)

Biotin Conjugated (3)

Carrier-free (3)

FITC Conjugated (3)

HRP Conjugated (3)

Preservative Free (1)

Unconjugated (39)

Epitope

C-Terminus (8)

aa2-150 (3)

pTyr114 (2)

50-130 aa (1)

60-140 aa, Internal (1)

Glu116 (1)

Internal (1)

aa1-147 (1)

aa19-54 (1)

aa80-129 (1)

aa81-130 (1)

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Publications

No (60)

Sample Type

Adherent Cell Cultures (1)

Cell Lysates (1)

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

6His, N-terminus (2)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (6)

Species

Human (7)

Mouse (1)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (1)

Select

IHC-plus™ FHIT Antibody LS-B10125

(4.0) Rating

Antibody:

FHIT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

Select

FHIT Antibody (aa2-150, FITC) LS-C371314

Antibody:

FHIT Rabbit anti-Mouse Polyclonal (aa2-150) (FITC) Antibody

Reactivity:

Mouse

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

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FHIT Antibody LS-C404982

Antibody:

FHIT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

FHIT Antibody (Internal) LS-C352195

Antibody:

FHIT Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

Select

FHIT Antibody LS-C486471

Antibody:

FHIT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$412

Select

FHIT Antibody LS-C827130

Antibody:

FHIT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

FHIT Antibody LS-C665591

Antibody:

FHIT Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$371

Select

IHC-plus™ FHIT Antibody LS-B3166

(4.0) Rating

Antibody:

FHIT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$485

Select

FHIT Antibody LS-C416213

Antibody:

FHIT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

IHC-plus™ FHIT Antibody (aa80-129) LS-B13322

(4.0) Rating

Antibody:

FHIT Rabbit anti-Human Polyclonal (aa80-129) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

100 µl/$515

Select

FHIT Antibody (aa81-130) LS-C118449

Antibody:

FHIT Rabbit anti-Human Polyclonal (aa81-130) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

FHIT Antibody LS-C808442

Antibody:

FHIT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

FHIT Antibody (60-140 aa, Internal) LS-C383488

Antibody:

FHIT Rabbit anti-Human Polyclonal (60-140 aa, Internal) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

FHIT Antibody (Preservative Free) LS-C818013

Antibody:

FHIT Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC-P

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

Select

FHIT Antibody (Glu116) LS-C176023

Antibody:

FHIT Rabbit anti-Human Polyclonal (Glu116) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

FHIT Antibody LS-C401681

Antibody:

FHIT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

FHIT Antibody (clone OTI1D7) LS-C795950

Antibody:

FHIT Mouse anti-Human Monoclonal (OTI1D7) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

FHIT Antibody (clone OTI1D7, Carrier-free) LS-C792785

Antibody:

FHIT Mouse anti-Human Monoclonal (Carrier-free) (OTI1D7) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

FHIT Antibody (aa1-147) LS-C344033

Antibody:

FHIT Rabbit anti-Human Polyclonal (aa1-147) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

FHIT Antibody (clone OTI2C2) LS-C799124

Antibody:

FHIT Mouse anti-Human Monoclonal (OTI2C2) Antibody

Reactivity:

Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

FHIT Antibody LS-C827790

Antibody:

FHIT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

FHIT Antibody LS-C331341

Antibody:

FHIT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

FHIT Antibody (50-130 aa) LS-C381701

Antibody:

FHIT Rabbit anti-Human Polyclonal (50-130 aa) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

FHIT Antibody (clone OTI6B4) LS-C795949

Antibody:

FHIT Mouse anti-Human Monoclonal (OTI6B4) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

FHIT Antibody (clone OTI6B4, Carrier-free) LS-C792782

Antibody:

FHIT Mouse anti-Human Monoclonal (Carrier-free) (OTI6B4) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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