FGR

feline Gardner-Rasheed sarcoma viral oncogene homolog

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.

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Products

Antibodies (45)

Proteins (9)

ELISA Kits (1)

Type

Custom (1)

Over-Expression Lysate (6)

Primary (45)

Recombinant (3)

Target

FGR (55)

Reactivity

Human (45)

Mouse (10)

Rat (7)

Bovine (3)

Chimpanzee (3)

Gibbon (3)

Application

IHC (20)

IHC-P (8)

WB (40)

ELISA (22)

IF (2)

Peptide-ELISA (4)

Host

rabbit (35)

mouse (9)

goat (1)

Product Group

IHCPlus (2)

Isotype

IgG (28)

IgG1 (3)

IgG2a,k (5)

Clonality

monoclonal mc (8)

polyclonal pc (37)

Clone

1B12 (1)

3B11 (1)

3F2 (1)

3G10 (1)

4C12 (1)

6G2 (2)

Format

96-Well Microplate (1)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (2)

Unconjugated (29)

Epitope

aa3-33 (7)

C-Terminus (4)

30-110 aa, Internal (1)

350-430 aa (1)

aa232-265 (1)

aa381-430 (1)

aa517-529 (1)

aa61-110 (1)

p412 (1)

Publications

No (55)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (7)

Species

Human (6)

Source

293T Cells (3)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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IHC-plus™ FGR Antibody (clone 3G10) LS-B12872

(4.0) Rating

Antibody:

FGR Mouse anti-Human Monoclonal (3G10) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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FGR Antibody (clone 1B12) LS-C133193

Antibody:

FGR Mouse anti-Human Monoclonal (1B12) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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IHC-plus™ FGR Antibody (clone 6G2) LS-B4106

(4.0) Rating

Antibody:

FGR Mouse anti-Human Monoclonal (6G2) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

FGR Antibody (clone 3B11) LS-C133192

Antibody:

FGR Mouse anti-Human Monoclonal (3B11) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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FGR Antibody (aa3-33) LS-C99377

Antibody:

FGR Rabbit anti-Human Polyclonal (aa3-33) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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FGR Antibody LS-C677948

Antibody:

FGR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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FGR Antibody (clone 4C12) LS-C133194

Antibody:

FGR Mouse anti-Human Monoclonal (4C12) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

Select

FGR Antibody (clone 3F2) LS-C133195

Antibody:

FGR Mouse anti-Human Monoclonal (3F2) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

Select

FGR Antibody LS-C814009

Antibody:

FGR Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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FGR Antibody (aa3-33) LS-C327374

Antibody:

FGR Rabbit anti-Human Polyclonal (aa3-33) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

FGR Antibody (aa3-33, Biotin) LS-C277338

Antibody:

FGR Rabbit anti-Human Polyclonal (aa3-33) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

FGR Antibody (aa3-33, FITC) LS-C277339

Antibody:

FGR Rabbit anti-Human Polyclonal (aa3-33) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

FGR Antibody (aa3-33, APC) LS-C277337

Antibody:

FGR Rabbit anti-Human Polyclonal (aa3-33) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

FGR Antibody (aa3-33, Azide-free, HRP) LS-C277341

Antibody:

FGR Rabbit anti-Human Polyclonal (aa3-33) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

FGR Antibody (aa3-33, PE) LS-C277340

Antibody:

FGR Rabbit anti-Human Polyclonal (aa3-33) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

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FGR Antibody (30-110 aa, Internal) LS-C382667

Antibody:

FGR Rabbit anti-Human Polyclonal (30-110 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

FGR Antibody (350-430 aa) LS-C382668

Antibody:

FGR Rabbit anti-Human Polyclonal (350-430 aa) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

FGR Antibody (clone 6G2) LS-C758571

Antibody:

FGR Mouse anti-Human Monoclonal (6G2) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$518

Select

FGR Antibody LS-C331873

Antibody:

FGR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

FGR Antibody LS-C831284

Antibody:

FGR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

FGR Antibody (aa232-265) LS-C356304

Antibody:

FGR Rabbit anti-Mouse Polyclonal (aa232-265) Antibody

Reactivity:

Rat

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

FGR Antibody LS-C822573

Antibody:

FGR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

FGR Antibody (p412) LS-C825381

Antibody:

FGR Rabbit anti-Human Polyclonal (p412) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

FGR Antibody (aa61-110) LS-C118770

Antibody:

FGR Rabbit anti-Human Polyclonal (aa61-110) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

FGR Antibody (aa381-430) LS-C198959

Antibody:

FGR Rabbit anti-Human Polyclonal (aa381-430) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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