Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal (IgG) to Human FGFR1 / FGF Receptor 1
Human, Mouse, Rat
Human FGFR1 / FGF Receptor 1
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Western blot (1:1000)
Specificity and Use
FGFR1 / FGF Receptor 1 antibody was raised against synthetic peptide (KLH coupled) corresponding to residues surrounding Tyr653/654 of human FGFR-1 (the corresponding sequences are the same in FGFR-2, -3 and -4).
Detects overexpressed levels of Tyr653/654-phosphorylated FGF receptors. This antibody slightly cross-reacts with activated PDGF receptor and insulin/IGF-I receptors but does not cross-react with other tyrosine-phosphorylated proteins. Species cross-reactivity: Human, mouse and rat.
Suitable for use in Western Blot. Western Blot: 1:1000.
10 mM sodium HEPES, pH 7.5, 150 mM sodium chloride, 0.1 mg/ml BSA, 50% glycerol.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB.