FBXW8

F-box and WD repeat domain containing 8

Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695).

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Products

Antibodies (18)

Proteins (6)

Type

Over-Expression Lysate (4)

Primary (18)

Recombinant (2)

Target

FBXW8 (24)

Reactivity

Human (18)

Mouse (7)

Bat (3)

Bovine (6)

Chimpanzee (6)

Gibbon (6)

Guinea pig (3)

Horse (3)

Pig (6)

Rabbit (6)

Application

IHC (9)

WB (16)

Flo (7)

ELISA (9)

Host

rabbit (18)

Isotype

IgG (12)

Clonality

polyclonal pc (18)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (7)

Epitope

aa270-299 (7)

C-Terminus (4)

aa504-553 (4)

Publications

No (24)

Tag

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (4)

Species

Human (4)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Select

FBXW8 Antibody (aa270-299) LS-C166096

Antibody:

FBXW8 Rabbit anti-Human Polyclonal (aa270-299) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, IHC, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

FBXW8 Antibody (aa504-553) LS-C102670

Antibody:

FBXW8 Rabbit anti-Human Polyclonal (aa504-553) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

FBXW8 Antibody (aa504-553, HRP) LS-C460371

Antibody:

FBXW8 Rabbit anti-Human Polyclonal (aa504-553) (HRP) Antibody

Reactivity:

Rabbit, Guinea pig, Bovine, Pig, Bat, Gibbon, Human, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

FBXW8 Antibody (aa504-553, Biotin) LS-C460369

Antibody:

FBXW8 Rabbit anti-Human Polyclonal (aa504-553) (Biotin) Antibody

Reactivity:

Rabbit, Guinea pig, Bovine, Pig, Bat, Gibbon, Human, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

FBXW8 Antibody (aa504-553, FITC) LS-C460370

Antibody:

FBXW8 Rabbit anti-Human Polyclonal (aa504-553) (FITC) Antibody

Reactivity:

Rabbit, Guinea pig, Bovine, Pig, Bat, Gibbon, Human, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

FBXW8 Antibody (aa270-299) LS-C321332

Antibody:

FBXW8 Rabbit anti-Human Polyclonal (aa270-299) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

FBXW8 Antibody (aa270-299, Biotin) LS-C246938

Antibody:

FBXW8 Rabbit anti-Human Polyclonal (aa270-299) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

FBXW8 Antibody (aa270-299, FITC) LS-C246939

Antibody:

FBXW8 Rabbit anti-Human Polyclonal (aa270-299) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

FBXW8 Antibody (aa270-299, PE) LS-C246940

Antibody:

FBXW8 Rabbit anti-Human Polyclonal (aa270-299) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

FBXW8 Antibody (aa270-299, APC) LS-C246937

Antibody:

FBXW8 Rabbit anti-Human Polyclonal (aa270-299) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

FBXW8 Antibody (aa270-299, Azide-free, HRP) LS-C249980

Antibody:

FBXW8 Rabbit anti-Human Polyclonal (aa270-299) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• PE
• APC
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • PE
  • APC
  • HRP, Azide-free

Select

FBXW8 Antibody LS-C830068

Antibody:

FBXW8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

FBXW8 Antibody LS-C831274

Antibody:

FBXW8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

FBXW8 Antibody LS-C178371

Antibody:

FBXW8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$332

Select

FBXW8 Antibody (C-Terminus) LS-C116624

Antibody:

FBXW8 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

FBXW8 Antibody (C-Terminus, HRP) LS-C460374

Antibody:

FBXW8 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Rabbit, Bovine, Pig, Horse, Gibbon, Human, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

FBXW8 Antibody (C-Terminus, Biotin) LS-C460372

Antibody:

FBXW8 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Rabbit, Bovine, Pig, Horse, Gibbon, Human, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

FBXW8 Antibody (C-Terminus, FITC) LS-C460373

Antibody:

FBXW8 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Rabbit, Bovine, Pig, Horse, Gibbon, Human, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

Human FBXW8 Protein (Recombinant GST, N-terminus) (aa499-598) - LS-G62165

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

Select

Human FBXW8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G94090

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.5 kDa

Price:

20 µg/$215

Select

Human FBXW8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G94091

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.2 kDa

Price:

20 µg/$150

Select

FBXW8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105795

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.2 kDa

Price:

100 µg/$494

Select

Human FBXW8 Protein (Recombinant His, N-Terminal) - LS-G145112

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

67.2 kDa

Price:

50 µg/$419

Select

FBXW8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114615

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.5 kDa

Price:

100 µg/$710

Viewing 1-24 of 24 product results

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