Mouse FASLG / Fas Ligand

Hamster

Mouse (tested or 100% immunogen sequence identity)

IgG Monoclonal

MFL4

R. Phycoerythrin. Also available conjugated with FITC.

Protein G purified

Unmodified

B6 mouse FasL/BHK cells.

Recognizes both mouse and rat CD178, otherwise known as Fas Ligand/ CD95L, a 40kD type II transmembrane glycoprotein and member of the TNF/NGF superfamily, expressed by activated T cells and NK cells, which can be induced on a variety of cells by radiation, heat shock, chemotherapeutic agents and viral infection. CD178 acts as a key effector of cytotoxicity and in the regulation of immune responses. The binding of CD178 to its receptor CD95 (Fas), induces Fas-mediated apoptosis of target cells, and may be involved in the induction of peripheral tolerance and neutrophil chemotaxis. The binding of decoy receptor 3 (DcR3) to CD178 has been shown to inhibit CD178-mediated apoptosis. Clone MFL4 is reported to block CD178/CD95 induced apoptosis.

• Flow Cytometry (1:1)
• Applications tested for the base form of this product only

The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

PBS, 0.09% Sodium Azide, 5% Sucrose, 1% BSA

Reconstitute with distilled water.

Store at 4°C. Do not freeze. Store undiluted. Protect from light. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P48023 NCBI: NM_000639 NP_000630.1